coumarin

Coumarin is a chemical compound/poison found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. It has clinical value as the precursor for several anticoagulants, notably warfarin.

Coumarin 6 (Coumarin VI) is a fluorescent dye frequently used to facilitate the traceability of drug delivery systems in vitro.

7-(3'-Carboxybutoxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6209 and the CAS number is 16851-01-7.

The combination of Valproic acid with Coumarin-3-carboxylic acid (3-Carboxycoumarin) suppresses the proliferation and migration of lung cancer cells via EGFR/VEGFR2/c-Met-Akt-NF-κB signaling pathways; this combination may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of lung cancer.

Coumarin 7 is a natural product.

7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6207 and the CAS number is 118584-19-3.

7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) is a 5-Hydroxytryptamine Receptor Subtype 1E (HTR1E) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a Galanin Receptor 2 (GALR2) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a galanin receptor 2 (GalR2) antagonist. 7-Amino-4-(trifluoromethyl)coumarin is a HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 inhibitor with the activity value of 21 uM.

3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes.

Ethyl coumarin-3-carboxylate, a coumarin derivative, serves as a pseudo-template for the synthesis of Molecularly Imprinted Polymers (MIPs) that specifically recognize aflatoxins.

Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2/ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax.

4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.

4-Methyl-6-Methoxycoumarin is a natural product isolated from Eupatorium pauciflorum.

3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.

4-Methoxycoumarine has antitumour effects.

4-Ethoxycoumarin has antimicrobial activity.

4,7-DIHYDROXYCOUMARIN is a naturally occurring coumarin derivative found in a variety of plants, including parsley and chamomile. It has been found to inhibit the activity of several enzymes, including cytochrome P450, cyclooxygenase and lipoxygenase. It can also bind to DNA, regulate gene expression, and inhibit cell cycle progression. It can also induce apoptosis in tumor cells and reduce inflammation.

8-Acetyl-7-Hydroxycoumarin is a natural compound,with Antifungal and antibacterial activities

5-Geranoxy-7-methoxycoumarin shows antifungal activity.

Herniarin (Ayapanin) is a natural coumarin with antitumor effect.

Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.

6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.

1. Notopterol induces apoptosis and inhibits cell cycle-specific.

4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

Qianhucoumarin B, a coumarin derivative, is isolated from the roots of Peucedanum praeruptorum, known in traditional Chinese medicine as Qianhu [1].

Qianhucoumarin C, a coumarin derivative isolated from the roots of Peucedanum praeruptorum, exhibits potential medicinal properties such as anti-inflammatory, antioxidant, and anticancer effects. This compound plays a significant role in various industrial processes, most notably in the manufacturing of pharmaceuticals and herbal medicines [1].

Qianhucoumarin D, a pyranocoumarin natural product, is extracted from the roots of Peucedanum praeruptorum and is utilized in research pertaining to inflammation and cancer [1].

6-(3-Methyl-2-oxobutyroyl)-7-methoxycoumarin is a natural product for research related to life sciences. The catalog number is TN5877 and the CAS number is 2188162-96-9.

Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.

Licofuranocoumarin is a minor flavonoid extracted from Glycyrrhiza uralensis (licorice).

Isoglycycoumarin, a flavonoid derived from the roots of Glycyrrhiza uralensis, serves as a highly selective probe for human cytochrome P450 2A6.

6-Hydroxycoumarin (6-hydroxychromen-2-one) exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a human CA9, CA12 inhibitor.

Qianhucoumarin E is a natural product of Peucedanum, Apiaceae. The catalog number is TN4873 and the CAS number is 156041-02-0. Qianhucoumarin E can be used as a reference standard.

7-methoxy-8-hydroxy-4-methylcoumarin is a compound isolated from Citrus aurantium.

Peucedanocoumarin I is a natural product of Peucedanum, Apiaceae. The catalog number is TN4755 and the CAS number is 130464-55-0. Peucedanocoumarin I can be used as a reference standard.

7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.

Arnocoumarin, a natural compound, is isolatable from X. arnottianum MAXIM [1].

7-Hydroxy-5-methoxycoumarin, a phloroglucinol-type furocoumarin, serves as a potent natural insect antifeedant [1].

5,7-Dihydroxycoumarin 7-O-β-D-glucopyranoside, a natural compound, can be isolated from the roots of Morus nigra [1].

Coumarinic acid serves as a brain-penetrating inhibitor of AChE (acetylcholinesterase) and β-amyloid, with applications in anti-Alzheimer's drug research [1].

Toddanol ((-)-Toddanol) is a coumarin extracted from the roots of Toddalia.

Baihuaqianhuoside (Praeroside) is a coumarin glycoside. Baihuaqianhuoside can be isolated from the roots of Passiflora and Hindenia solanacea and was first isolated from P. japonicum. Baihuaqianhuoside has anti-inflammatory activity in vitro and can be used in studies of inflammation. Baihuaqianhuoside has been shown to be effective against 1,1- scavenging effect of diphenyl-2-propenyl hydrazide radical and inhibition of 2,2'-azobis(2-amidinopropane) dihydrochloride-induced liposome oxidation.

Ent-toddalolactone is a natural compound belonging to the coumarin group, derived from amphotericin. It has anti-inflammatory and anti-cancer activity.

(+)-6-(2-Hydroxy-3-methoxy-3-methylbutyl is a structural isomer of Ent-toddalolactone, which belongs to the coumarin group.

Micromarin F (E-Methylarnottinin) is a coumarin derivative extracted from the stems of Micromelum minutum Wight et Arn.

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors

5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia. 2012 Jul;83(5):968-72. [2]. Yi-Ping Chin, et al. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives. Arch Pharm (Weinheim). 2011 Jun;344(6):386-93.

7-Hydroxy-4-methyl-8-nitrocoumarin is a derivative of coumarin.

7-Ethoxy-4-Methylcoumarin is considered an inhibitor of enzymes in cells and has been used in studies of enzyme inhibition and has been used to study the effects of various drugs on the human body.

6-Hydroxy-4-methylcoumarin (6-Hydroxy-4-Methyl-2H-Chromen-2-One) is a secondary metabolite of coumarin, which has anticancer effects.