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Antileishmanial agent-17
Antileishmanial agent-17
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Antileishmanial agent-17
Catalog No. T78964Cas No. 2934738-40-4
Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine reductase and DHFR-TS. Efficacy against the promastigote form is highlighted by an IC50 value of 0.40 μM, and against the amastigote form, an IC50 of 0.68 μM, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine reductase and DHFR-TS. Efficacy against the promastigote form is highlighted by an IC50 value of 0.40 μM, and against the amastigote form, an IC50 of 0.68 μM, respectively. |
| In vitro | Antileishmanial agent-17 (compound 14b) inhibits the folate pathway, demonstrating inhibition rates of 82% and 91% for folates, and 88% and 91% for dihydrofolates at concentrations of 20 μM and 100 μM, respectively [1]. Furthermore, it exhibits low cytotoxicity against African green monkey kidney cells (VERO cells), with a CC50 of 244.3 μM [1]. |
| Molecular Weight | 511.61 |
| Formula | C27H37N5O5 |
| Cas No. | 2934738-40-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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