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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $700 | 6-8 weeks | |
5 mg | $1,800 | 6-8 weeks |
Description | Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival. |
In vitro | Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence emitted by PAF-primed cells[2]. |
In vivo | Tulopafant (RP 59227) effectively reduces myocardial infarct size and decreases the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1]. Histological examination shows a marked decrease in interstitial hemorrhage and platelet and granulocyte deposition in cardiac xenograft capillaries when recipient animals are pretreated with Tulopafant[1]. |
Alias | RP 59227 |
Molecular Weight | 425.5 |
Formula | C25H19N3O2S |
Cas No. | 116289-53-3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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