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Tulopafant
😃Good
Catalog No. T17178Cas No. 116289-53-3
Alias RP 59227
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
Tulopafant
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Purity: 99.38%
Catalog No. T17178Alias RP 59227Cas No. 116289-53-3
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 6-8 weeks | |
| 5 mg | $1,800 | 6-8 weeks |
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Purity:99.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival. |
| In vitro | Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence emitted by PAF-primed cells[2]. |
| In vivo | Tulopafant (RP 59227) effectively reduces myocardial infarct size and decreases the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs[1]. Histological examination shows a marked decrease in interstitial hemorrhage and platelet and granulocyte deposition in cardiac xenograft capillaries when recipient animals are pretreated with Tulopafant[1]. |
| Alias | RP 59227 |
| Molecular Weight | 425.5 |
| Formula | C25H19N3O2S |
| Cas No. | 116289-53-3 |
| Smiles | C(NC1=CC(C(=O)C2=CC=CC=C2)=CC=C1)(=O)C3=C4N(C(SC4)C=5C=CC=NC5)C=C3 |
| Relative Density. | 1.32g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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