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Apafant
Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.
Catalog No. T14300Cas No. 105219-56-5
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Apafant
Catalog No. T14300Alias WEB-2086, WEB2086, WEB 2086Cas No. 105219-56-5
Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $428 | In Stock | |
| 25 mg | $698 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs. |
| Targets&IC50 | PAF:（ki）9.9 nM |
| In vivo | Guinea pigs were actively sensitized and OA solution was instilled into the eyes of guinea pigs on Days 15 and 17 to elicit the allergic conjunctivitis. To examine the effects of Apafant on allergic conjunctivitis, Apafant ophthalmic solution was topically administered 0.1%, 1%, q.i.d. through Days 14 to 17. Compared to the controls (vehicle treatments), the animals treated with Apafant ophthalmic solution showed significantly reduced clinical symptoms (redness and edema) and itch-scratch responses in both the first and second antigen challenges. [1] |
| Alias | WEB-2086, WEB2086, WEB 2086 |
| Molecular Weight | 455.96 |
| Formula | C22H22ClN5O2S |
| Cas No. | 105219-56-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL(65.80 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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