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CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $129 | In Stock | |
5 mg | $569 | In Stock | |
10 mg | $892 | In Stock |
Description | CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor. |
In vitro | CV-6209 (0.2-2 μM; pretreatment for 30 min) inhibited PAF-induced degranulation of LAD2 and hLMC MC; CV-6209 (30 nM) inhibited the release of [3H]5-hydroxytryptamine from rabbit platelets stimulated by PAF [4]. |
In vivo | CV-6209 (i.v.) inhibited PAF (0.3 μg/kg; i.v.) induced hypotension in rats (ED50=0.009 mg/kg) but had no effect on arachidonic acid, histamine, bradykinin and isobarbital-induced hypotension [4]. CV-6209 (66 μg; i.v.) reduced asparaginase-induced hypersensitivity compared to untreated sensitized mice [5]. |
Alias | CV6209, CV 6209 |
Molecular Weight | 642.31 |
Formula | C34H60ClN3O6 |
Cas No. | 100488-87-7 |
Smiles | [Cl-].O=C(OCC(OC)COC(=O)N(C(=O)C)CC=1C=CC=C[N+]1CC)NCCCCCCCCCCCCCCCCCC |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (124.55 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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