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CV-6209

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Catalog No. T27102Cas No. 100488-87-7
Alias CV6209, CV 6209

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

CV-6209

CV-6209

🥰Excellent
Purity: 100%
Catalog No. T27102Alias CV6209, CV 6209Cas No. 100488-87-7
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
Pack SizePriceAvailabilityQuantity
1 mg$129In Stock
5 mg$569In Stock
10 mg$892In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
In vitro
CV-6209 (0.2-2 μM; pretreatment for 30 min) inhibited PAF-induced degranulation of LAD2 and hLMC MC; CV-6209 (30 nM) inhibited the release of [3H]5-hydroxytryptamine from rabbit platelets stimulated by PAF [4].
In vivo
CV-6209 (i.v.) inhibited PAF (0.3 μg/kg; i.v.) induced hypotension in rats (ED50=0.009 mg/kg) but had no effect on arachidonic acid, histamine, bradykinin and isobarbital-induced hypotension [4].
CV-6209 (66 μg; i.v.) reduced asparaginase-induced hypersensitivity compared to untreated sensitized mice [5].
AliasCV6209, CV 6209
Chemical Properties
Molecular Weight642.31
FormulaC34H60ClN3O6
Cas No.100488-87-7
Smiles[Cl-].O=C(OCC(OC)COC(=O)N(C(=O)C)CC=1C=CC=C[N+]1CC)NCCCCCCCCCCCCCCCCCC
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (124.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5569 mL7.7844 mL15.5688 mL77.8440 mL
5 mM0.3114 mL1.5569 mL3.1138 mL15.5688 mL
10 mM0.1557 mL0.7784 mL1.5569 mL7.7844 mL
20 mM0.0778 mL0.3892 mL0.7784 mL3.8922 mL
50 mM0.0311 mL0.1557 mL0.3114 mL1.5569 mL
100 mM0.0156 mL0.0778 mL0.1557 mL0.7784 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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