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Vaborbactam

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Purity:98.45%

ee:100%

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COA CSFC HNMR HPLC LCMS

Vaborbactam

Catalog No. T17210Cas No. 1360457-46-0

Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.

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Pack Size	Price	Availability
2 mg	Inquiry	5 days
25 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks
100 mg	Inquiry	8-10 weeks

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Product Introduction

Bioactivity

Description	Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
In vitro	The β-lactamase inhibitor vaborbactam can also form an acyl-enzyme complex with Pseudomonas aeruginosa PBP3. We found that vaborbactam inhibits PBP3 (IC50 of 262 μM), and its binding to PBP3 increases the protein thermal stability by about 2°C[1].
In vivo	In a neutropenic mouse thigh infection model, the administration of 100 mg/kg meropenem alone and in combination with various doses of vaborbactam against Klebsiella pneumoniae was evaluated. The results showed that intraperitoneal injection of 300 mg/kg meropenem combined with 50 mg/kg vaborbactam resulted in the greatest reduction in bacterial counts compared to the untreated control group[2].
Alias	RPX7009

Chemical Properties

Molecular Weight	297.14
Formula	C12H16BNO5S
Cas No.	1360457-46-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 2 mg/mL (6.73 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
10 mM	0.3365 mL	1.6827 mL	3.3654 mL	16.8271 mL
20 mM	0.1683 mL	0.8414 mL	1.6827 mL	8.4135 mL
50 mM	0.0673 mL	0.3365 mL	0.6731 mL	3.3654 mL
100 mM	0.0337 mL	0.1683 mL	0.3365 mL	1.6827 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc