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VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $108 | 35 days | |
10 mg | $198 | 35 days | |
50 mg | $568 | 35 days |
Description | VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research. |
Targets&IC50 | mGluR4:693 nM (EC50) |
In vitro | VU0155041 sodium (10 μM) did not affect NMDA receptor currents in medium spiny neurons in the striatum, indicating that it does not antagonize NMDA receptor activity.[1] |
Alias | VU 0155041 sodium salt |
Molecular Weight | 338.16 |
Formula | C14H14Cl2NNaO3 |
Cas No. | 1259372-69-4 |
Smiles | ClC1=CC(Cl)=CC(NC([C@H]2[C@H](CCCC2)C([O-])=O)=O)=C1.[Na+] |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | H2O: 8.00 mg/mL (23.66 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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