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VU0155041 sodium
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Catalog No. T23507Cas No. 1259372-69-4
Alias VU 0155041 sodium salt
VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
VU0155041 sodium
😃Good
Catalog No. T23507Alias VU 0155041 sodium saltCas No. 1259372-69-4
VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 35 days | |
| 10 mg | Inquiry | 35 days | |
| 50 mg | Inquiry | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research. |
| Targets&IC50 | mGluR4:693 nM (EC50) |
| In vitro | VU0155041 sodium (10 μM) did not affect NMDA receptor currents in medium spiny neurons in the striatum, indicating that it does not antagonize NMDA receptor activity.[1] |
| Alias | VU 0155041 sodium salt |
| Molecular Weight | 338.16 |
| Formula | C14H14Cl2NNaO3 |
| Cas No. | 1259372-69-4 |
| Smiles | ClC1=CC(Cl)=CC(NC([C@H]2[C@H](CCCC2)C([O-])=O)=O)=C1.[Na+] |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 8.00 mg/mL (23.66 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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