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VU0155041 sodium

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Catalog No. T23507Cas No. 1259372-69-4
Alias VU 0155041 sodium salt

VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.

VU0155041 sodium

VU0155041 sodium

😃Good
Catalog No. T23507Alias VU 0155041 sodium saltCas No. 1259372-69-4
VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
Pack SizePriceAvailabilityQuantity
5 mg$108 35 days
10 mg$198 35 days
50 mg$568 35 days
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Product Introduction

Bioactivity
Description
VU0155041 sodium is a positive allosteric modulator of mGluR4, promoting extinction in male rats and inhibiting the recovery of morphine-induced conditioned place preference. It alleviates hyperalgesia in nerve injury pain models, useful in neurodegenerative disease research.
Targets&IC50
mGluR4:693 nM (EC50)
In vitro
VU0155041 sodium (10 μM) did not affect NMDA receptor currents in medium spiny neurons in the striatum, indicating that it does not antagonize NMDA receptor activity.[1]
AliasVU 0155041 sodium salt
Chemical Properties
Molecular Weight338.16
FormulaC14H14Cl2NNaO3
Cas No.1259372-69-4
SmilesClC1=CC(Cl)=CC(NC([C@H]2[C@H](CCCC2)C([O-])=O)=O)=C1.[Na+]
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | Shipping with blue ice.
Solubility Information
H2O: 8.00 mg/mL (23.66 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.9572 mL14.7859 mL29.5718 mL147.8590 mL
5 mM0.5914 mL2.9572 mL5.9144 mL29.5718 mL
10 mM0.2957 mL1.4786 mL2.9572 mL14.7859 mL
20 mM0.1479 mL0.7393 mL1.4786 mL7.3930 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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