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WEHI-539 hydrochloride
Catalog No. T13337Cas No. 2070018-33-4
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.
WEHI-539 hydrochloride
Catalog No. T13337Cas No. 2070018-33-4
WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.
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Product Introduction
Bioactivity
Chemical Properties
| Description | WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM. |
| Targets&IC50 | BCL-XL:1.1 nM |
| In vitro | WEHI-539 hydrochloride is a selective Bcl-XL inhibitor that enhances NSC 241240-induced caspase 3/7 activity, PARP cleavage, and annexin V labeling. As a single agent, WEHI-539 induces significant PARP cleavage in Ovcar-4 (5 μM in Ovcar-4) and Ovsaho (1 μM in Ovsaho) cells[2]. |
| Molecular Weight | 620.18 |
| Formula | C31H30ClN5O3S2 |
| Cas No. | 2070018-33-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (80.62 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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