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YM758

Name: YM758
Brand: TargetMol
SKU: T13374
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

YM758 is an inhibitor of If current channel.

Catalog No. T13374Cas No. 312752-85-5

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Purity:99.69%

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COA HPLC HNMR

YM758

Catalog No. T13374Cas No. 312752-85-5

YM758 is an inhibitor of If current channel.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$228	In Stock
10 mg	$372	In Stock
25 mg	$615	In Stock
50 mg	$869	In Stock
100 mg	$1,170	In Stock
500 mg	$2,350	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock

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Product Introduction

Bioactivity

Description	YM758 is an inhibitor of If current channel.
In vitro	YM758 inhibits rOct1- (IC50 = 23.8 μM) and hOCT1- (IC50 = 40.5 μM) mediated [3H]MPP uptake in a concentration-dependent manner. YM758 inhibits OATP1B1-mediated [3H]E217βG uptake in a concentration-dependent manner(IC50 = 13.0 μM). YM758 shows no inhibitory effect on OATP1B3-mediated [3H]E217βG uptake[1].
In vivo	In tachycardia-induced dogs, YM758 (0.03, 0.1, and 0.3 mg/kg; i.v.) plasma concentrations rapidly decrease with t1/2s of 1.62, 4.93, and 1.63 h, respectively. The CLtot values are1.71, 1.69, and 1.48 L/h/kg, and Vdss values amount to 3.19, 5.78, and 2.94 L/kg accordingly[2]. The radioactivity in the rat eyeballs after dosing 14C-YM758 is extracted. The radioactivity recovery is 97.1% at 4 h and 67.1% at 24 h. In the eyeball at 4 h after administration, YM758 (the unchanged drug) is the main compound detected (66.7%)[3].

Chemical Properties

Molecular Weight	469.55
Formula	C₂₆H₃₂FN₃O₄
Cas No.	312752-85-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (191.7 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1297 mL	10.6485 mL	21.2970 mL	106.4849 mL
5 mM	0.4259 mL	2.1297 mL	4.2594 mL	21.2970 mL
10 mM	0.2130 mL	1.0648 mL	2.1297 mL	10.6485 mL
20 mM	0.1065 mL	0.5324 mL	1.0648 mL	5.3242 mL
50 mM	0.0426 mL	0.2130 mL	0.4259 mL	2.1297 mL
100 mM	0.0213 mL	0.1065 mL	0.2130 mL	1.0648 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

YM758YM 758YM-758