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Z433927330

🥰Excellent
Catalog No. T13381Cas No. 1005883-72-6

Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).

Z433927330

Z433927330

🥰Excellent
Purity: 99.78%
Catalog No. T13381Cas No. 1005883-72-6
Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).
Pack SizePriceAvailabilityQuantity
1 mg36 €In Stock
5 mg88 €In Stock
10 mg140 €In Stock
25 mg278 €In Stock
50 mg408 €In Stock
100 mg562 €In Stock
200 mg743 €In Stock
1 mL x 10 mM (in DMSO)93 €In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
Z433927330 is a potent and selective Aquaporin-7 (AQP7) inhibitor (IC50 of 0.2).
Targets&IC50
AQP7 (mouse):~0.2 µM , AQP3 (mouse):~0.7 µM , AQP9 (mouse):~1.1 µM
In vitro
Z433927330 inhibits glycerol permeability(IC50 : 0.6 μM).
Chemical Properties
Molecular Weight364.4
FormulaC20H20N4O3
Cas No.1005883-72-6
SmilesCCOC(=O)c1ccc(NC(=O)NCc2ccc(cc2)-n2cccn2)cc1
Relative Density.1.23 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 280 mg/mL (768.39 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7442 mL13.7212 mL27.4424 mL137.2119 mL
5 mM0.5488 mL2.7442 mL5.4885 mL27.4424 mL
10 mM0.2744 mL1.3721 mL2.7442 mL13.7212 mL
20 mM0.1372 mL0.6861 mL1.3721 mL6.8606 mL
50 mM0.0549 mL0.2744 mL0.5488 mL2.7442 mL
100 mM0.0274 mL0.1372 mL0.2744 mL1.3721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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