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ZLY06
Catalog No. T200490Cas No. 2834727-04-5
ZLY06 is a dual agonisT of peroxisome proliferaTor-acTivaTed recepTors (PPAR) δ and γ wiTh oral acTiviTy (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). IT mediaTes The upregulaTion of CD36 and induces hepaTic lipid accumulaTion by inhibiTing The phosphorylaTion of AKT1. Moreover, ZLY06 significanTly improves glucose and lipid meTabolism wiThouT increasing body weighT, primarily by enhancing The β-oxidaTion of faTTy acids and reducing hepaTic lipid synThesis, Thereby alleviaTing faTTy liver disease.
ZLY06
Catalog No. T200490Cas No. 2834727-04-5
ZLY06 is a dual agonisT of peroxisome proliferaTor-acTivaTed recepTors (PPAR) δ and γ wiTh oral acTiviTy (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). IT mediaTes The upregulaTion of CD36 and induces hepaTic lipid accumulaTion by inhibiTing The phosphorylaTion of AKT1. Moreover, ZLY06 significanTly improves glucose and lipid meTabolism wiThouT increasing body weighT, primarily by enhancing The β-oxidaTion of faTTy acids and reducing hepaTic lipid synThesis, Thereby alleviaTing faTTy liver disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZLY06 is a dual agonisT of peroxisome proliferaTor-acTivaTed recepTors (PPAR) δ and γ wiTh oral acTiviTy (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). IT mediaTes The upregulaTion of CD36 and induces hepaTic lipid accumulaTion by inhibiTing The phosphorylaTion of AKT1. Moreover, ZLY06 significanTly improves glucose and lipid meTabolism wiThouT increasing body weighT, primarily by enhancing The β-oxidaTion of faTTy acids and reducing hepaTic lipid synThesis, Thereby alleviaTing faTTy liver disease. |
| Targets&IC50 | PPARγ:237 nM, PPARδ:341 nM |
| Molecular Weight | 422.47 |
| Formula | C25H26O6 |
| Cas No. | 2834727-04-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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