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(+)-Afzelechin (Afzelechin) is isolated from Eysenhardtia subcoriacea. It is an α-glucosidase activity inhibitor, offering neuroprotective effects against glutamate-induced neurotoxicity in HT22 cells and improving reduced glutathione levels in rat pancreas homogenates.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $458 | Backorder | |
5 mg | $1,018 | Backorder |
Description | (+)-Afzelechin (Afzelechin) is isolated from Eysenhardtia subcoriacea. It is an α-glucosidase activity inhibitor, offering neuroprotective effects against glutamate-induced neurotoxicity in HT22 cells and improving reduced glutathione levels in rat pancreas homogenates. |
Targets&IC50 | α-glucosidase:0.13 mM(ID50) |
In vitro | Treatment of human umbilical vein endothelial cells (HUVECs) with (+)-Afzelechin (20 μM, 6h) effectively inhibited the production of iNOS and prevented LPS-induced NO synthesis. (+)-AfzelechinC (2-20 μM, 6h) demonstrated its anti-inflammatory ability by down-regulating IL-1β expression in LPS-treated HUVEC. [1] (+)-Afzelechin improves the efficacy of sepsis induced ALI by modulating TLR4/NF-κB, PI3K/Akt, Hippo, and Rho signaling pathways to reduce inflammation. [2] |
In vivo | (+)-Afzelechin (0.04-0.4 mg/kg, intravenously), results showed significantly reduced iNOS expression in mice with LPS-induced lung injury models, indicating the anti-inflammatory activity of (+)-Afzelechin in vivo. [1] |
Alias | Afzelechin |
Molecular Weight | 274.27 |
Formula | C15H14O5 |
Cas No. | 2545-00-8 |
Smiles | OC1=C2C(O[C@@H]([C@@H](O)C2)C3=CC=C(O)C=C3)=CC(O)=C1 |
Relative Density. | 1.492 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (291.68 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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