Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 162.00 | |
25 mg | In stock | $ 318.00 | |
50 mg | In stock | $ 490.00 | |
100 mg | In stock | $ 725.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 108.00 |
Description | NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene. |
Targets&IC50 | Glucocerebrosidase:31 nM |
In vitro | NCGC00092410 increased GC activity in N370S mutant fibroblasts. Treatment of Gaucher's fibroblasts with 40μM NCGC00092410 for 10-70 h increased the lysosomal content of GC in Gaucher's fibroblasts. NCGC00092410 inhibited GC activity with different substrate concentrations in a dose-dependent manner. [1]. |
Synonyms | ML008 |
Molecular Weight | 353.46 |
Formula | C21H27N3O2 |
CAS No. | 442898-34-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37.5 mg/mL (106.1 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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NCGC00092410 442898-34-2 Metabolism Glucosidase ML 008 NCGC-00092410 NCGC 00092410 ML-008 ML008 inhibitor inhibit