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(Z)-10-Hydroxynortriptyline

Name: (Z)-10-Hydroxynortriptyline
Brand: TargetMol
SKU: T13377
Rating: 4.5 (1 reviews)

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Catalog No. T13377Cas No. 47132-19-4

Alias cis-10-hydroxy Nortriptyline, (Z)-10-Hydroxy Nortriptyline

(Z)-10-Hydroxynortriptyline ((Z)-10-Hydroxy Nortriptyline) is an active metabolite of Nortriptyline, inhibiting norepinephrine uptake with antidepressant activity, useful for studying neurological disorders.

(Z)-10-Hydroxynortriptyline

😃Good

Catalog No. T13377Alias cis-10-hydroxy Nortriptyline, (Z)-10-Hydroxy NortriptylineCas No. 47132-19-4

Pack Size	Price	Availability	Quantity
1 mg	$215	35 days

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	(Z)-10-Hydroxynortriptyline ((Z)-10-Hydroxy Nortriptyline) is an active metabolite of Nortriptyline, inhibiting norepinephrine uptake with antidepressant activity, useful for studying neurological disorders.
In vivo	(Z)-10-Hydroxynortriptyline(3.5-7 mg/kg, intravenously) causes pronounced bradycardia in pigs with reduced blood pressure and cardiac output. [1]
Alias	cis-10-hydroxy Nortriptyline, (Z)-10-Hydroxy Nortriptyline

Chemical Properties

Molecular Weight	279.38
Formula	C₁₉H₂₁NO
Cas No.	47132-19-4
Smiles	C(\CCNC)=C/1\C=2C(C(O)CC=3C1=CC=CC3)=CC=CC2
Relative Density.	1.164 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (143.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5794 mL	17.8968 mL	35.7935 mL	178.9677 mL
5 mM	0.7159 mL	3.5794 mL	7.1587 mL	35.7935 mL
10 mM	0.3579 mL	1.7897 mL	3.5794 mL	17.8968 mL
20 mM	0.1790 mL	0.8948 mL	1.7897 mL	8.9484 mL
50 mM	0.0716 mL	0.3579 mL	0.7159 mL	3.5794 mL
100 mM	0.0358 mL	0.1790 mL	0.3579 mL	1.7897 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc