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10β,17β-dihydroxyestra-1,4-dien-3-one
Catalog No. T10036Cas No. 549-02-0
Alias DHED
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage.
10β,17β-dihydroxyestra-1,4-dien-3-one
Catalog No. T10036Alias DHEDCas No. 549-02-0
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $99 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-selective prodrug of 17β-estradiol, which has neuroprotective effects, improves cognitive dysfunction, and can be used to study brain damage. |
| In vivo | The effect of 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) on PR expression has also been evaluated on animals. PR expression in brains taken from morphine-treated rats manifested the same response to 10β,17β-dihydroxyestra-1,4-dien-3-one or EE as in OVX rats not treated with morphine. These animals were treated with the test compounds (10β,17β-dihydroxyestra-1,4-dien-3-one 30 and 100μg/kg, EE 200μg/kg, and vehicle) via oral gavage twice per day. As indicated by optical density on film exposures, that induction of the highly estrogen-responsive gene was three fold higher in the 10β,17β-dihydroxyestra-1,4-dien-3-one - and EE-treated groups than in the vehicle-treated animals. |
| Alias | DHED |
| Molecular Weight | 288.38 |
| Formula | C18H24O3 |
| Cas No. | 549-02-0 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (277.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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