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18β-Glycyrrhetinic acid

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Catalog No. T0036Cas No. 471-53-4
Alias Glycyrrhetin, Enoxolone

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

18β-Glycyrrhetinic acid

18β-Glycyrrhetinic acid

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Purity: 99.64%
Catalog No. T0036Alias Glycyrrhetin, EnoxoloneCas No. 471-53-4
18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
Pack SizePriceAvailabilityQuantity
500 mg$43In Stock
5 g$61Backorder
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:99.64%
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Product Introduction

Bioactivity
Description
18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
In vitro
MTS assay demonstrates that 24 h treatment of Enoxolone suppresses cell proliferation in both cell lines in a dose-dependent manner. Enoxolone at 160 μM significantly decreases the percentage of viable cells to around 40.5±10.5% in A549 and 38.3±4.6% in NCI-H460 (p<0.01 respectively). When the cells are treated with 320 μM Enoxolone, a greater inhibitory effects on cell proliferation is shown, as the percentage of viable cells is below 30% compare with untreated controls (p<0.001). Treatment with Enoxolone at 160 μM and 320 μM decreases the levels of full-length PARP and increases the levels of cleaved-PARP.
In vivo
Rats in Enoxolone+Triptolide (TP) group which receive low-dose Enoxolone (50?mg/kg) have significant reductions in the three serum parameters when compare with TP rats. Rats in Enoxolone+TP group which receive the high-dose Enoxolone (100?mg/kg) have slightly lowered the levels of three liver enzymes, the reductions do not reach statistical significance compare with TP group. Contrastingly, preadministration of low-dose Enoxolone protects animals from TP-induced hepatic lesions. On the contrary, low-dose Enoxolone (50?mg/kg) markedly suppresses the release of the four cytokines above.
AliasGlycyrrhetin, Enoxolone
Chemical Properties
Molecular Weight470.68
FormulaC30H46O4
Cas No.471-53-4
Smiles[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)C3CC[C@@]12C)C(O)=O
Relative Density.0.9967 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (116.85 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1246 mL10.6229 mL21.2459 mL106.2293 mL
5 mM0.4249 mL2.1246 mL4.2492 mL21.2459 mL
10 mM0.2125 mL1.0623 mL2.1246 mL10.6229 mL
20 mM0.1062 mL0.5311 mL1.0623 mL5.3115 mL
50 mM0.0425 mL0.2125 mL0.4249 mL2.1246 mL
100 mM0.0212 mL0.1062 mL0.2125 mL1.0623 mL

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