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2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC).
Pack Size | Price | Availability | Quantity |
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200 mg | $29 | In Stock | |
1 mL x 10 mM (in DMSO) | $29 | In Stock |
Description | 2'-Deoxycytidine hydrochloride is the hydrochloride form of 2'-Deoxycytidine, an important deoxyribonucleoside analog commonly used in DNA synthesis and potentially anticancer, and its derivative Gemcitabine has been developed as an anticancer drug.2'-Deoxycytidine 2'-Deoxycytidine hydrochloride protects mice from the lethal toxicity of cytosine arabinoside(araC). |
In vitro | Methods: Effects of 2'-Deoxycytidine hydrochloride (1 mM) on the cytotoxicity of 5FU against mouse myeloma SP2/0-Ag14 (SP2/0) cells lacking hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) and RH4 hybridoma cells possessing HGPRT under asynchronous conditions. Results: In both SP2/0 and RH4 cells, 5FU-reduced cell viability was restored by co-treatment but not pre-treatment with 2'-Deoxycytidine hydrochloride, but the effect of the former was often greater than that of the latter, suggesting that HGPRT may be involved in the interaction, although this may not be the primary mechanism. [1] |
Alias | Deoxyribose cytidine hydrochloride, Deoxycytidine hydrochloride, Cytosine deoxyriboside hydrochloride |
Molecular Weight | 263.68 |
Formula | C9H14ClN3O4 |
Cas No. | 3992-42-5 |
Smiles | O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=CC(N)=N1.Cl |
Relative Density. | no data available |
Storage | keep away from moisture | store at 4°C | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 30 mg/mL (113.77 mM), Sonication is recommended. DMSO: 20 mg/mL (75.85 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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