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2-Phenyl-2-(1-piperidinyl)propane

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Purity:99.71%

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COA HPLC HNMR

2-Phenyl-2-(1-piperidinyl)propane

Catalog No. T7788Cas No. 92321-29-4

2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, is a chemical compound.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$80	In Stock
25 mg	$163	In Stock
50 mg	$247	In Stock
100 mg	$372	In Stock
200 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, is a chemical compound.
Targets&IC50	CYP2B6:5.6 μM (Ki), CYP3A:200 μM (IC50), CYP2C19:>300 μM (IC50), CYP2E1:>300 μM (IC50), CYP2A6:>300 μM (IC50), CYP1A2:>300 μM (IC50), CYP2C8:>300 μM (IC50), CYP2B6:5.1 μM (IC50), CYP2C9:>300 μM (EC50), CYP2D6:74 μM (IC50)
In vivo	2-Phenyl-2-(1-piperidinyl)propane (PPP) inactivated the 7-(benzyloxy)resorufin O-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats with a K(I) of 11 microM.?The 7-ethoxy-4-(trifluoromethyl)coumarin O-deethylation activity of purified rat liver P450 2B1 and expressed human P450 2B6 was inactivated by PPP in a reconstituted system containing NADPH-cytochrome P450 reductase and lipid[1]

Chemical Properties

Molecular Weight	203.32
Formula	C14H21N
Cas No.	92321-29-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (99.8 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9184 mL	24.5918 mL	49.1836 mL	245.9178 mL
5 mM	0.9837 mL	4.9184 mL	9.8367 mL	49.1836 mL
10 mM	0.4918 mL	2.4592 mL	4.9184 mL	24.5918 mL
20 mM	0.2459 mL	1.2296 mL	2.4592 mL	12.2959 mL
50 mM	0.0984 mL	0.4918 mL	0.9837 mL	4.9184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

2 Phenyl 2 (1 piperidinyl)propaneReversibleinhibitCYPsCytochrome P450CYP2B6CYP3AInhibitorCYP2D62-Phenyl-2-(1-piperidinyl)propane2Phenyl2(1piperidinyl)propane

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