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25,26-Dihydroxyvitamin D3

Name: 25,26-Dihydroxyvitamin D3
Brand: TargetMol
SKU: T13490
Price: 46 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13490Cas No. 29261-12-9

Alias 25,26-Dihydroxycholecalciferol

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.

25,26-Dihydroxyvitamin D3

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Purity: 95.47%

Catalog No. T13490Alias 25,26-DihydroxycholecalciferolCas No. 29261-12-9

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.

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1 mg	2.202 €	Backorder

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Purity:95.47%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.
In vitro	24,25 and 25,26 diOHD3 (0.125-0.250 mug) were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The 'bone calcium mobilization' of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3 [2].
In vivo	24,25 and 25,26-Dihydroxyvitamin D3 (0.125-0.250 mug) were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26-Dihydroxyvitamin D3 increased serum calcium moderately, but the increment was only significant with 24,25-Dihydroxyvitamin D3 [2].
Alias	25,26-Dihydroxycholecalciferol

Chemical Properties

Molecular Weight	416.64
Formula	C₂₇H₄₄O₃
Cas No.	29261-12-9
Smiles	C[C@@]12[C@](\C(=C\C=C\3/C(=C)CC[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(CO)(C)O)C)[H])[H]
Relative Density.	1.06g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (192.01 mM.), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4002 mL	12.0008 mL	24.0015 mL	120.0077 mL
5 mM	0.4800 mL	2.4002 mL	4.8003 mL	24.0015 mL
10 mM	0.2400 mL	1.2001 mL	2.4002 mL	12.0008 mL
20 mM	0.1200 mL	0.6000 mL	1.2001 mL	6.0004 mL
50 mM	0.0480 mL	0.2400 mL	0.4800 mL	2.4002 mL
100 mM	0.0240 mL	0.1200 mL	0.2400 mL	1.2001 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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