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4-IPP

4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).

Catalog No. T7844Cas No. 41270-96-6

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Purity:99.59%

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COA LCMS LCMS HPLC HNMR

4-IPP

Catalog No. T7844Cas No. 41270-96-6

4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$97	In Stock
10 mg	$163	In Stock
25 mg	$276	In Stock
50 mg	$397	In Stock
100 mg	$588	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF).
In vitro	4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade.
In vivo	In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction.?Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation.
Cell Research	Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours
Animal Research	Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks
Alias	4-Iodo-6-phenylpyrimidine

Chemical Properties

Molecular Weight	282.08
Formula	C₁₀H₇IN₂
Cas No.	41270-96-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (106.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5451 mL	17.7255 mL	35.4509 mL	177.2547 mL
5 mM	0.7090 mL	3.5451 mL	7.0902 mL	35.4509 mL
10 mM	0.3545 mL	1.7725 mL	3.5451 mL	17.7255 mL
20 mM	0.1773 mL	0.8863 mL	1.7725 mL	8.8627 mL
50 mM	0.0709 mL	0.3545 mL	0.7090 mL	3.5451 mL
100 mM	0.0355 mL	0.1773 mL	0.3545 mL	1.7725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

4-IPPInhibitorosteoclastogenesis4IPPMIFinhibit4 IPPRANKLosteoblast