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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $163 | In Stock | |
25 mg | $276 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $588 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | 4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF). |
In vitro | 4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-κB signaling cascade. |
In vivo | In the murine model of pathologic osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction.?Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation. |
Cell Research | Cell Line:BMMs. Concentration:0.5 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 25 μM, 50 μM, 100 μM, 200 μM. Incubation Time:24 hours, 72 hours |
Animal Research | Animal Model:8-weeks-old C57BL/6J male mice. Dosage:1 mg/kg, 5 mg/kg. Administration:Intraperitoneal injection; every 2 days; for 8 weeks |
Alias | 4-Iodo-6-phenylpyrimidine |
Molecular Weight | 282.08 |
Formula | C10H7IN2 |
Cas No. | 41270-96-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (106.35 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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