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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $93 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $297 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $672 | In Stock | |
500 mg | $1,380 | In Stock | |
1 mL x 10 mM (in DMSO) | $90 | In Stock |
Description | 5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells also leads to elevation of reactive oxygen species and activation of p38, JNK and ERK. |
In vitro | Estrogen receptor positive (ER+; MCF-7 and T47D) breast cancer cells, estrogen receptor negative (ER?; CRL2335, MDA-MB-231, and MDA-MB-468) breast cancer cells, and nonmalignant MCF-10A cells are treated with 5F 203 or vehicle control (0.1% DMSO) for 72 h. Nonmalignant MCF-10A breast epithelial cells and MDA-MB-231 breast cancer cells were resistant to 5F 203 treatment, whereas the other cell lines showed varying sensitivity to 5F 203. |
Alias | 5F-203, NSC-703786 |
Molecular Weight | 258.31 |
Formula | C14H11FN2S |
Cas No. | 260443-89-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (96.78 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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