store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
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1 mg | Inquiry | $ 328.00 | |
5 mg | Inquiry | Inquiry | |
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Description | 5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
Targets&IC50 | Src:6600 nM, B-RAF VE:6300 nM, TAK1:8.1 nM, MEK1:411 nM, VEGFR-3:110 nM, PDGFR-β:340 nM, VEGFR-2:52 nM, FLT3:170 nM |
In vitro | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
Synonyms | FR148083, L783279, LL-Z 1640-2 |
Molecular Weight | 362.37 |
Formula | C19H22O7 |
CAS No. | 253863-19-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (110.38 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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5Z-7-Oxozeaenol 253863-19-3 Angiogenesis MAPK Microbiology/Virology Tyrosine Kinase/Adaptors MEK FLT VEGFR PDGFR Antibiotic Src Vascular endothelial growth factor receptor L 783279 MAP kinase kinase kinase, MEKK, MAPKKK inhibit FR148083 5Z7Oxozeaenol L-783279 FR 148083 FR-148083 L783279 5Z 7 Oxozeaenol Inhibitor LL-Z 1640-2 MAP3K inhibitor