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7-Hydroxymethotrexate
🥰Excellent
Catalog No. T20339Cas No. 5939-37-7
Alias NSC-380963, NSC380963, NSC-380962, NSC380962, NSC 380963, NSC 380962
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.Methotrexate is also an inhibitor of metabolism.
7-Hydroxymethotrexate
🥰Excellent
Purity: 95%
Catalog No. T20339Alias NSC-380963, NSC380963, NSC-380962, NSC380962, NSC 380963, NSC 380962Cas No. 5939-37-7
7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.Methotrexate is also an inhibitor of metabolism.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $312 | In Stock | |
| 5 mg | $749 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,530 | In Stock | |
| 50 mg | $2,450 | In Stock |
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Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.Methotrexate is also an inhibitor of metabolism. |
| In vitro | With an affinity for DHFR markedly lower (>100-fold) than Methotrexate (MTX), 7-Hydroxymethotrexate (7-OHMTX)[1]. |
| In vivo | Administered intravenously at a dose of 4 mg/kg, 7-Hydroxymethotrexate (7-OHMTX) exhibits a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg[1]. |
| Alias | NSC-380963, NSC380963, NSC-380962, NSC380962, NSC 380963, NSC 380962 |
| Molecular Weight | 470.44 |
| Formula | C20H22N8O6 |
| Cas No. | 5939-37-7 |
| Smiles | NC1=C2C(NC(=O)C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=NC(N)=N1 |
| Relative Density. | 1.68g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 0.66 mg/mL (1.4 mM), Sonification is recommended.  | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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