Shopping Cart
- Remove All
Your shopping cart is currently empty
9-cis-Retinal
9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin.
Catalog No. T19169Cas No. 514-85-2
Select Batch
Contact us for more batch information
Resource Download
9-cis-Retinal
Catalog No. T19169Cas No. 514-85-2
9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $123 | 35 days | |
| 5 mg | $494 | 35 days | |
| 10 mg | $658 | 35 days |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "9-cis-Retinal"
Glycerol
T477656-81-5
Glycerol or glycerin is a colourless, odourless, viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations. Glycerol is an important component of trigl
- $41
Size
QTY
Sucrose
T473357-50-1
Sucrose (D-(+)-Saccharose) is a nonreducing disaccharide composed of glucose and fructose linked via their anomeric carbons.
- $29
Size
QTY
Thymidine
Cited
TWP291150-89-5
Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase.
- $45
Size
QTY
CitedFerulic Acid Cited
T22151135-24-6
Ferulic Acid (Coniferic acid) is a highly abundant phenolic phytochemical and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong.It can be absorbed by the small intestine and excreted through the urine.
- $30
Size
QTY
CitedDaidzein Cited
T1238486-66-8
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
- $45
Size
QTY
CitedGuanidine hydrochloride
T041550-01-1
Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
- $29
Size
QTY
Naringin Cited
T059510236-47-2
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
- $35
Size
QTY
CitedFumaric acid
T3763110-17-8
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
- $32
Size
QTY
Formamide
T476775-12-7
Formamide (NSC-748) is a metabolite used for biological monitoring of workers exposed to N-N-dimethylformamide (DMF). There is a case of significant association between ever having been exposed to DMF and subsequent development of prostate cancer.
- $41
Size
QTY
Oleamide
T13802301-02-0
Oleamide (Oleic acid amide) is an endogenous fatty acid amide and can be used in the synthesis of de novo in the mammalian nervous system.
- $50
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | 9-cis-Retinal is a retinoid with Kd of 8 nM and 5 nM for cellular retinol binding protein-I (CRBP-1) and CRBP-II, respectively. 9-cis-Retinal accelerates the differentiation and maturation of rod photoreceptors in retinal organoids, reduces the toxicity of unliganded opsins, and can be used to study congenital stationary night blindness caused by G90D rhodopsin. |
| In vitro | b>METHODS: The binding of 9-cis-retinol, 9-cis-retinal, and 9-cis-RA to CRBPI and CRBPII was monitored through fluorescence spectroscopy, and the data were analyzed using nonlinear regression to determine the apparent dissociation constant K'(d) . RESULTS: CRBPI and CRBPII bind to 9-cis-retinol (K'(d), 11nM and 68nM) and 9-cis-retinal (K'(d), 8nM and 5nM) respectively with high affinity; CRBPI or CRBPII have not been observed yet. Significant binding of CRBPII to 9-cis-RA. [1] |
| In vivo | b>METHODS: After recording baseline ERG, IRBP-deficient mice were allowed to rest for 12 hours, and 0.375 mg of 9-cis-retinal was injected intraperitoneally. ERG before and after were analyzed to test 11-cis-retinal in cones of IRBP-deficient mice. retinal defects. RESULTS: 9-cis-retinal treatment significantly increased cone photoreceptor responses; the cones of IRBP-deficient mice were particularly sensitive to exogenous 9-cis-retinal, and the recovery of cone photoreceptor function to WT levels indicated that IRBP deletion had minimal Cone dysfunction in mice is caused by 11-cis-retinal deficiency. [4] |
| Molecular Weight | 284.44 |
| Formula | C20H28O |
| Cas No. | 514-85-2 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (35.16 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy 9-cis-Retinal | purchase 9-cis-Retinal | 9-cis-Retinal cost | order 9-cis-Retinal | 9-cis-Retinal chemical structure | 9-cis-Retinal in vivo | 9-cis-Retinal in vitro | 9-cis-Retinal formula | 9-cis-Retinal molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.