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Adalimumab

Catalog No. T9901 CAS 331731-18-1

Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Adalimumab, CAS 331731-18-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 213.00
5 mg	In stock	$ 449.00
10 mg	In stock	$ 713.00

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Purity: 99.50%

AntibodyUnit: 54.5 mg/mL

Purity: 99.50%

AntibodyUnit: 50 mg/mL

Purity: 98.00%

AntibodyUnit: 4.48 mg/mL

Purity: 98.00%

AntibodyUnit: 10.6 mg/mL

Purity: 95.00%

AntibodyUnit: 18.42 mg/mL

Purity: 95.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
Cell Research	Objective: Adalimumab induces apoptosis of THP-1 cells. Concentrations: 10μg/mL. Incubation Time: 6, 12, 18, 24, 30 hours. Method: THP-1 cells (0.5×106) were incubated with anti-FcRI mAb and anti-FcRII mAb, and then cultured with adalimumab, infliximab, huIgG or vehicle (PBS) alone as indicated. LPS (1μg/mL) was added in all culture conditions. Apoptosis was analyzed at different time points by staining with annexin V-FITC and propidium iodide, Apo2.7-PE-conjugated antibody, or 7AAD.
Animal Research	Objective: The distribution of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis. Formulation: PBS. Dosages: 2 mg/kg

Molecular Weight	148 kDa
CAS No.	331731-18-1

Storage

store at low temperature

store at -20°C

Solubility Information

DMSO: Insoluble

H2O: 10 mM

References and Literature

1. Mease PJ, et al. Adalimumab: an anti-TNF agent for the treatment of psoriatic arthritis. Expert Opin Biol Ther. 2005 Nov;5(11):1491-504. 2. Elsakkar MG, et al. Adalimumab ameliorates OVA-induced airway inflammation in mice: Role of CD4(+) CD25(+) FOXP3(+) regulatory T-cells. Eur J Pharmacol. 2016 Sep 5;786:100-108. 3. Biesemann N, et al. Additive efficacy of a bispecific anti-TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis. Sci Transl Med. 2023 Feb;15(681):eabq4419.

Citations

1. Lei A, Yu H, Lu S, et al.A second-generation M1-polarized CAR macrophage with antitumor efficacy.Nature Immunology.2023: 1-15.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Adalimumab 331731-18-1 Apoptosis TNF inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.