Aristeromycin

Aristeromycin (U 99468) is a broad-spectrum antiviral antibiotic that targets RNA viruses and is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY).

Catalog No. T10369Cas No. 19186-33-5

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Purity:98.96%

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Aristeromycin

Catalog No. T10369Cas No. 19186-33-5

Aristeromycin (U 99468) is a broad-spectrum antiviral antibiotic that targets RNA viruses and is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY).

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Pack Size	Price	Availability
1 mg	$212	7-10 days
2 mg	$315	7-10 days
5 mg	$533	7-10 days

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Product Introduction

Bioactivity

Description	Aristeromycin (U 99468) is a broad-spectrum antiviral antibiotic that targets RNA viruses and is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY).
In vitro	DZNeP and Aristeromycin exhibit potent inhibitory activity against AHCY. Treatment of prostate cancer cells with DZNeP leads to accumulation of SAH and reduction in levels of homocysteine and histone H3K27 methylation. Confirmation of SAH accumulation and growth inhibition was achieved upon siRNA-mediated knockdown of AHCY[1].
Alias	U 99468

Chemical Properties

Molecular Weight	265.27
Formula	C₁₁H₁₅N₅O₃
Cas No.	19186-33-5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 30 mg/mL (113.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7697 mL	18.8487 mL	37.6974 mL	188.4872 mL
5 mM	0.7539 mL	3.7697 mL	7.5395 mL	37.6974 mL
10 mM	0.3770 mL	1.8849 mL	3.7697 mL	18.8487 mL
20 mM	0.1885 mL	0.9424 mL	1.8849 mL	9.4244 mL
50 mM	0.0754 mL	0.3770 mL	0.7539 mL	3.7697 mL
100 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc