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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $128 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $413 | In Stock | |
50 mg | $579 | In Stock | |
100 mg | $793 | In Stock | |
1 mL x 10 mM (in DMSO) | $158 | In Stock |
Description | BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. |
In vitro | BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1]. |
Alias | BMX kinase inhibitor |
Molecular Weight | 524.59 |
Formula | C29H24N4O4S |
Cas No. | 1431525-23-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMF: 9 mg/mL (17.16 mM), Sonication is recommended. DMSO: 8 mg/mL (15.25 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/DMF
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