Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 139.00 | |
5 mg | In stock | $ 425.00 | |
10 mg | In stock | $ 618.00 | |
25 mg | In stock | $ 962.00 | |
50 mg | In stock | $ 1,290.00 |
Description | Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL). |
Targets&IC50 | Viability:30.9 μg/mL, EGFR:0.7 microM, v-Src:1 microM |
In vitro | By using different chromatographic techniques and appropriate spectroscopic methods, the seven naphthoquinones were described: deoxyshikonin ( 1 ), isobutyrylshikonin ( 2 ), α±-methylbutyrylshikonin ( 3 ), acetylshikonin ( 4 ), Beta-Hydroxyisovalerylshikonin( 5 ), 5,8-O-dimethyl isobutyrylshikonin ( 6 ) and 5,8-O-dimethyl deoxyshikonin ( 7 ). Among the tested compounds, 3 and 4 exhibited the highest antibacterial activities toward all tested bacterial species (MIC50 and MIC90 for gram positive bacteria: 6.40 μg/mL-12.79 μg/mL and 6.82 μg/mL-13.60 μg/mL, respectively; for gram negative bacteria: 4.27 μg/mL-8.53 μg/mL and 4.77 μg/mL-9.54 μg/mL, respectively). Also, naphthoquinones 3 and 4 exhibited strong cytotoxic activity against MDA-MB-231 cells (IC50 values 86.0 μg/mL and 80.2 μg/mL, respectively), while compounds 1 , 3 , 4 and 5 significantly decreased viability of HCT116 cells (IC50 values of 97.8 μg/mL, 15.2 μg/mL, 24.6 μg/mL and 30.9 μg/mL, respectively)[1] |
Source |
Molecular Weight | 388.41 |
Formula | C21H24O7 |
CAS No. | 7415-78-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.75 mM)
You can also refer to dose conversion for different animals. More
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Beta-Hydroxyisovalerylshikonin 7415-78-3 Angiogenesis Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation JAK/STAT signaling Metabolism PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors AMPK Src Prostaglandin Receptor Fatty Acid Synthase Tyrosine Kinases EGFR inhibit Inhibitor ErbB-1 BetaHydroxyisovalerylshikonin Beta Hydroxyisovalerylshikonin Epidermal growth factor receptor b-Hydroxyisovalerylshikonin HER1 β-Hydroxyisovalerylshikonin inhibitor