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CCG-50014

CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

Catalog No. T6434Cas No. 883050-24-6

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Purity:98.53%

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COA LCMS LCMS HNMR HPLC

CCG-50014

Catalog No. T6434Cas No. 883050-24-6

CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

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Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$48	In Stock
25 mg	$98	In Stock
50 mg	$158	In Stock
100 mg	$251	In Stock
200 mg	$373	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock

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Product Introduction

Bioactivity

Description	CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Targets&IC50	RGS4:30 nM
In vitro	CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2]
Alias	CCG 50014

Chemical Properties

Molecular Weight	316.35
Formula	C₁₆H₁₃FN₂O₂S
Cas No.	883050-24-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 59 mg/mL (186.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1611 mL	15.8053 mL	31.6106 mL	158.0528 mL
5 mM	0.6322 mL	3.1611 mL	6.3221 mL	31.6106 mL
10 mM	0.3161 mL	1.5805 mL	3.1611 mL	15.8053 mL
20 mM	0.1581 mL	0.7903 mL	1.5805 mL	7.9026 mL
50 mM	0.0632 mL	0.3161 mL	0.6322 mL	3.1611 mL
100 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5805 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc