Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 36.00 | |
5 mg | In stock | $ 54.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 209.00 | |
50 mg | In stock | $ 378.00 | |
100 mg | In stock | $ 562.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM. |
Targets&IC50 | RGS4:30 nM |
In vitro | CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2] |
Synonyms | CCG 50014 |
Molecular Weight | 316.35 |
Formula | C16H13FN2O2S |
CAS No. | 883050-24-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 59 mg/mL (186.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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CCG-50014 883050-24-6 GPCR/G Protein GTPase Regulators of G-protein Signaling Regulator of G-protein Signaling RGS Protein inhibit CCG 50014 Inhibitor CCG50014 inhibitor