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CCG-50014

Catalog No. T6434 CAS 883050-24-6

Synonyms: CCG 50014

CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

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CCG-50014, CAS 883050-24-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 36.00
5 mg	In stock	$ 54.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 209.00
50 mg	In stock	$ 378.00
100 mg	In stock	$ 562.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 98.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
Targets&IC50	RGS4:30 nM
In vitro	CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys?). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4?Gαo protein?protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. [1] [2]

Synonyms	CCG 50014
Molecular Weight	316.35
Formula	C16H13FN2O2S
CAS No.	883050-24-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 59 mg/mL (186.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Blazer LL, et al. Biochemistry, 2011, 50(15), 3181-3192. 2. Turner EM, et al. ACS Med Chem Lett, 2012, 3(2), 146-150.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

BQU57 CID-4785700 QS11 NAV-2729 Compound C108 IMM-01 Dynamin inhibitory peptide Acetate CCG-63802

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCG-50014 883050-24-6 GPCR/G Protein GTPase Regulators of G-protein Signaling Regulator of G-protein Signaling RGS Protein inhibit CCG 50014 Inhibitor CCG50014 inhibitor

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