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CCT020312

Catalog No. T14902 CAS 324759-76-4

CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.

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CCT020312, CAS 324759-76-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 63.00
5 mg	In stock	$ 146.00
10 mg	In stock	$ 255.00
25 mg	In stock	$ 429.00
50 mg	In stock	$ 635.00
100 mg	In stock	$ 883.00
500 mg	In stock	$ 1,830.00

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Purity: 98.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCT020312 is a selective activator of EIF2AK3 and PERK. CCT020312 durably inhibits cell proliferation and elicits the phosphorylation of EIF2A.
In vitro	In HT29 cells, CCT020312 reduces the P-S608-pRB signal with a linear response between 1.8 and 6.1 μM in a concentration-dependent manner. CCT020312(10 μM) decreases G1/S cyclins D1, D2, E, and A, reduces the CDK catalytic subunit CDK2 and increased the level of the p27KIP1[1].
In vivo	In wild-type mice, intraperitoneal injection of CCT020312 (1-5 mg/kg) increases PERK and NRF2 phosphorylation of brain homogenates. In P301S tau transgenic mice, intraperitoneal injection of CCT020312 (2 mg/kg) behaves better in the Morris water maze test[2].

Molecular Weight	650.4
Formula	C31H30Br2N4O2
CAS No.	324759-76-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (138.4 mM), Sonication is recommended.

References and Literature

1. Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568. 2. Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9(3):371-384.

Related compound libraries

This product is contained In the following compound libraries：

Endoplasmic Reticulum Stress Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Bioactive Compound Library

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Keywords

CCT020312 324759-76-4 Apoptosis PERK CCT-020312 CCT 020312 inhibitor inhibit

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