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CGS 15435

CGS 15435
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.
Catalog No. T10783Cas No. 95853-92-2
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Purity:99.63%
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CGS 15435

Catalog No. T10783Cas No. 95853-92-2
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.
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Pack SizePriceAvailabilityQuantity
1 mg$197In Stock
5 mg$478In Stock
10 mg$654In Stock
25 mg$990In Stock
50 mg$1,330In Stock
100 mg$1,750In Stock
1 mL x 10 mM (in DMSO)$558In Stock
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Product Introduction

Bioactivity
Description
CGS 15435 is a potent thromboxen (TxA2) synthetase inhibitor (IC50: 1 nM). CGS 15435 acts on PGI2 synthase, cyclooxygenase and liposynthase with much less selectivity than on thromboxin synthase.
Targets&IC50
TXA2:1 nM
In vitro
CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).[1]
In vivo
The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.[1]
Chemical Properties
Molecular Weight356.85
FormulaC20H21ClN2O2
Cas No.95853-92-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.57 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8023 mL14.0115 mL28.0230 mL140.1149 mL
5 mM0.5605 mL2.8023 mL5.6046 mL28.0230 mL
10 mM0.2802 mL1.4011 mL2.8023 mL14.0115 mL

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