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CH-223191

Catalog No. T2448 CAS 301326-22-7

Synonyms: CH 223191

CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).

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CH-223191, CAS 301326-22-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Targets&IC50	AhR:30 nM

Synonyms	CH 223191
Molecular Weight	333.395
Formula	C19H19N5O
CAS No.	301326-22-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 3.3 mg/mL (10 mM)

DMSO: 33.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim SH, et al. Mol Pharmacol. 2006, 69(6), 1871-1878. 2. Gramatzki D, et al. Oncogene. 2009, 28(28), 2593-2605. 3. Xie HQ, et al. Environ Health Perspect. 2013, 121(5), 613-618. 4. de Souza AR, et al. Toxicol Sci. 2014, 140(1), 204-223. 5. Wang K, Lv Q, Miao Y, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway[J]. Biochemical pharmacology. 2018 Sep;155:494-509.

Citations

1. Wang K, Lv Q, Miao Y, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochemical Pharmacology. 2018 Sep;155:494-509

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Stem Cell Differentiation Compound Library Nonsteroidal Anti-Inflammatory Compound Library Bioactive Lipid Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

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Keywords

CH-223191 301326-22-7 代谢免疫与炎症 AhR Aryl Hydrocarbon Receptor CH 223191 Inhibitor CH223191 inhibit inhibitor

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