Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 56.00 | |
10 mg | In stock | $ 98.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 296.00 | |
100 mg | In stock | $ 515.00 | |
200 mg | In stock | $ 739.00 | |
500 mg | In stock | $ 1,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR). |
Targets&IC50 | AhR:30 nM |
In vitro | Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. |
In vivo | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB. |
Synonyms | CH 223191 |
Molecular Weight | 333.39 |
Formula | C19H19N5O |
CAS No. | 301326-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 3.3 mg/mL (10 mM)
DMSO: 33.3 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CH-223191 301326-22-7 Immunology/Inflammation Metabolism AhR Aryl Hydrocarbon Receptor Inhibitor inhibit CH223191 CH 223191 inhibitor