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CKI-7

Catalog No. T19913   CAS 1177141-67-1
Synonyms: Serum and glucocorticoid-regulated kinase, inhibit, nestin, S6K, CKI-7 2HCl, Inhibitor, CK1, Casein Kinase, CKI7 2HCl, Ribosomal S6 Kinase (RSK), differentiation, SGK, CKI-7, Cyclin dependent kinase, neural, Serum-glucocorticoid regulated kinase, S6K1, MSK1, CKI 7 2HCl, CDK, CKI 7, Wnt, CKI7 dihydrochloride, CKI7, CKI 7 dihydrochloride, βIII-tubulin, CKI-7 dihydrochloride, Sox1

CKI-7 2HCl is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 2HCl also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.

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CKI-7, CAS 1177141-67-1
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description CKI-7 2HCl is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 2HCl also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.
Targets&IC50 CK1:6 μM(IC50), CK1:8.5 μM(Ki)
Synonyms Serum and glucocorticoid-regulated kinase, inhibit, nestin, S6K, CKI-7 2HCl, Inhibitor, CK1, Casein Kinase, CKI7 2HCl, Ribosomal S6 Kinase (RSK), differentiation, SGK, CKI-7, Cyclin dependent kinase, neural, Serum-glucocorticoid regulated kinase, S6K1, MSK1, CKI 7 2HCl, CDK, CKI 7, Wnt, CKI7 dihydrochloride, CKI7, CKI 7 dihydrochloride, βIII-tubulin, CKI-7 dihydrochloride, Sox1
Molecular Weight 358.67
Formula C11H14Cl3N3O2S
CAS No. 1177141-67-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 65 mg/ml (181.23 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Osakada F, et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009 Sep 1;122(Pt 17):3169-79. 2. Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrob Agents Chemother. 2014;58(3):1501-15. doi: 10.1128/AAC.02022-13. Epub 2013 Dec 23. PubMed PMID: 24366737; PubMed Central PMCID: PMC3957854. 3. Tian Y, Yue X, Luo D, Wazir R, Wang J, Wu T, Chen L, Liao B, Wang K. Increased proliferation of human bladder smooth muscle cells is mediated by physiological cyclic stretch via the PI3K SGK1 Kv1.3 pathway. Mol Med Rep. 2013 Jul;8(1):294-8. doi: 10.3892/mmr.2013.1473. Epub 2013 May 13. PubMed PMID: 23669863. 4. Boesger J, Wagner V, Weisheit W, Mittag M. Application of phosphoproteomics to find targets of casein kinase 1 in the flagellum of chlamydomonas. Int J Plant Genomics. 2012;2012:581460. doi: 10.1155/2012/581460. Epub 2012 Dec 18. PubMed PMID: 23316220; PubMed Central PMCID: PMC3536430.

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