Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During histone preparation, CMP-5 inhibits PRMT5 methyltransferase activity and recruitment of PRMT5/p65/HDAC3 complex on miR96 promoter.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 119.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | CMP-5 is an effective and selective small-molecule inhibitor of PRMT5. CMP-5 blocks EBV-driven B lymphocyte transformation and survival, but does not show this activity against PRMT1, PRMT4 and PRMT7 enzymes. During histone preparation, CMP-5 inhibits PRMT5 methyltransferase activity and recruitment of PRMT5/p65/HDAC3 complex on miR96 promoter. |
Targets&IC50 | hTh1 cells:26.9 μM , hTh2 cells:31.6 μM , MTH1 (cells):3.7 μM , MTH2 (cells):9.2 μM |
Molecular Weight | 315.41 |
Formula | C21H21N3 |
CAS No. | 880813-42-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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CMP-5 880813-42-3 Others CMP 5 CMP5 inhibitor inhibit