Powder: -20°C for 3 years | In solvent: -80°C for 2 years
CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 83.00 |
Description | CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431. |
Targets&IC50 | ACC2:61 nM, ACC1:53 nM |
Kinase Assay | Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit. |
Synonyms | CP 640186 HCl |
Molecular Weight | 522.08 |
Formula | C30H35ClN3O3 |
CAS No. | 591778-70-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 48 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CP-640186 hydrochloride 591778-70-0 Metabolism Acetyl-CoA Carboxylase HepG2 muscle fatty acid oxidation Inhibitor CP 640186 HCl CP 640186 CP640186 C2C12 CP-640186 human fibroblasts H460 muscle strips CP 640186 hydrochloride inhibit ACC, Acetyl Coenzyme A Carboxylase CP640186 hydrochloride inhibitor