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CP-640186 hydrochloride

Catalog No. T3622 CAS 591778-70-0

Synonyms: CP 640186 HCl

CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

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CP-640186 hydrochloride, CAS 591778-70-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 589.00
1 mL * 10 mM (in DMSO)	In stock	$ 83.00

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Purity: 99.04%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CP-640186 HCl is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
Targets&IC50	ACC2:61 nM, ACC1:53 nM
Kinase Assay	Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit.

Synonyms	CP 640186 HCl
Molecular Weight	522.08
Formula	C30H35ClN3O3
CAS No.	591778-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 48 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Harwood HJ Jr, et al. J Biol Chem. 2003 Sep 26;278(39):37099-111. ; 2. Yamashita T, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.;

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Inhibitor Library Anti-Metabolism Disease Compound Library Metabolism Compound Library Bioactive Compound Library Anti-Hypertension Compound Library Lipid Metabolism Compound Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library NO PAINS Compound Library

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Keywords

CP-640186 hydrochloride 591778-70-0 Metabolism Acetyl-CoA Carboxylase HepG2 muscle fatty acid oxidation Inhibitor CP 640186 HCl CP 640186 CP640186 C2C12 CP-640186 human fibroblasts H460 muscle strips CP 640186 hydrochloride inhibit ACC, Acetyl Coenzyme A Carboxylase CP640186 hydrochloride inhibitor

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