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PF-05175157

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Catalog No. T7163Cas No. 1301214-47-0

PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

PF-05175157

PF-05175157

🥰Excellent
Purity: 99.78%
Catalog No. T7163Cas No. 1301214-47-0
PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively
Pack SizePriceAvailabilityQuantity
5 mg57 €In Stock
10 mg92 €In Stock
25 mg183 €In Stock
50 mg365 €In Stock
100 mg563 €In Stock
1 mL x 10 mM (in DMSO)63 €In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively
Targets&IC50
ACC1 (rat):23.5 nM , ACC1 (human):27.0 nM , ACC2 (human):33.0 nM , ACC2 (rat):50.4 nM
In vivo
PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice, unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.
Animal Research
Pharmacokinetics was analyzed after a single oral dose of the compounds (in a 0.5% methyl cellulose suspension) administered to fasted male mice. A dose of 15 mg/kg for PF-05175157 or 100 mg/kg in the case of PF-05206574 and PF-06256254 was analyzed. Antiviral activity in vivo was determined using eight-week-old Swiss albino CD-1 female mice. Animals were treated with PF-05175157 (20 mg/kg) suspended in 1% carboxymethylcellulose by oral gavage twice a day from 1 d before infection with WNV (1 × 10^4 PFU/mouse intraperitoneally) and up to 7 days post-infection. Control mice were treated in parallel with drug vehicle (carboxymethylcellulose). For experiments evaluating the effect of genetic deletion of ACC2 gene on WNV infection, a breeding colony of C57BL/6 ACC2-/- mice was established from two heterozygous Acabtm1Dejs females . Age- and sex-matched eight-week-old ACC2-/- and control wild type (WT) mice were challenged with WNV (1 × 10^4 PFU/animal.). Animals were monitored daily and received water and food ad libitum.
Chemical Properties
Molecular Weight405.49
FormulaC23H27N5O2
Cas No.1301214-47-0
SmilesCC(C)n1ncc2CC3(CCN(CC3)C(=O)c3ccc4nc(C)[nH]c4c3)CC(=O)c12
Relative Density.1.38 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (73.98 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4662 mL12.3308 mL24.6615 mL123.3076 mL
5 mM0.4932 mL2.4662 mL4.9323 mL24.6615 mL
10 mM0.2466 mL1.2331 mL2.4662 mL12.3308 mL
20 mM0.1233 mL0.6165 mL1.2331 mL6.1654 mL
50 mM0.0493 mL0.2466 mL0.4932 mL2.4662 mL

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