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Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $46 | In Stock | |
1 mL x 10 mM (in DMSO) | $178 | In Stock |
Description | Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion. |
In vitro | The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent. |
In vivo | The vitamin K antagonist Coumetarol showed efficacy in both models after oral treatment, particularly demonstrating stronger thrombotic inhibition in the arteriolar junction model. Coumetarol was administered orally at a therapeutic dose of 25 mg/kg. Twice-daily administration for two consecutive days resulted in a significant 50% reduction in thrombus weight in the venous pause model and a significant 75% reduction in the arterial cleft shunt model. [1] |
Alias | Ph 137, Dicumoxane |
Molecular Weight | 380.35 |
Formula | C21H16O7 |
Cas No. | 4366-18-1 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 180 mg/mL (473.25 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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