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Coumetarol

Catalog No. T10867Cas No. 4366-18-1
Alias Ph 137, Dicumoxane

Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.

Coumetarol

Coumetarol

Purity: 99.01%
Catalog No. T10867Alias Ph 137, DicumoxaneCas No. 4366-18-1
Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
Pack SizePriceAvailabilityQuantity
2 mg$46In Stock
1 mL x 10 mM (in DMSO)$178In Stock
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Purity:99.01%
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Product Introduction

Bioactivity
Description
Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
In vitro
The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent.
In vivo
The vitamin K antagonist Coumetarol showed efficacy in both models after oral treatment, particularly demonstrating stronger thrombotic inhibition in the arteriolar junction model. Coumetarol was administered orally at a therapeutic dose of 25 mg/kg. Twice-daily administration for two consecutive days resulted in a significant 50% reduction in thrombus weight in the venous pause model and a significant 75% reduction in the arterial cleft shunt model. [1]
AliasPh 137, Dicumoxane
Chemical Properties
Molecular Weight380.35
FormulaC21H16O7
Cas No.4366-18-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 180 mg/mL (473.25 mM.), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6292 mL13.1458 mL26.2916 mL131.4579 mL
5 mM0.5258 mL2.6292 mL5.2583 mL26.2916 mL
10 mM0.2629 mL1.3146 mL2.6292 mL13.1458 mL
20 mM0.1315 mL0.6573 mL1.3146 mL6.5729 mL
50 mM0.0526 mL0.2629 mL0.5258 mL2.6292 mL
100 mM0.0263 mL0.1315 mL0.2629 mL1.3146 mL

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