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Coumetarol
🥰Excellent
Catalog No. T10867Cas No. 4366-18-1
Alias Ph 137, Dicumoxane
Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
Coumetarol
🥰Excellent
Purity: 99.01%
Catalog No. T10867Alias Ph 137, DicumoxaneCas No. 4366-18-1
Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $178 | In Stock |
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Purity:99.01%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Coumetarol (Dicumoxane) is a vitamin K antagonist and an oral anticoagulant that can be used to study arterial thrombotic occlusion. |
| In vitro | The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent. |
| In vivo | The vitamin K antagonist Coumetarol showed efficacy in both models after oral treatment, particularly demonstrating stronger thrombotic inhibition in the arteriolar junction model. Coumetarol was administered orally at a therapeutic dose of 25 mg/kg. Twice-daily administration for two consecutive days resulted in a significant 50% reduction in thrombus weight in the venous pause model and a significant 75% reduction in the arterial cleft shunt model. [1] |
| Alias | Ph 137, Dicumoxane |
| Molecular Weight | 380.35 |
| Formula | C21H16O7 |
| Cas No. | 4366-18-1 |
| Smiles | O=C1OC=2C=CC=CC2C(O)=C1C(C=3C(=O)OC=4C=CC=CC4C3O)COC |
| Relative Density. | 1.514 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 180 mg/mL (473.25 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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