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Coumetarol

Catalog No. T10867 CAS 4366-18-1

Synonyms: Ph 137, Dicumoxane

Coumetarol is an antagonist of vitamin K.

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Coumetarol, CAS 4366-18-1

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 46.00
1 mL * 10 mM (in DMSO)	5 days	$ 178.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Coumetarol is an antagonist of vitamin K.

In vitro

The vitamin K antagonist Coumetarol (Dicumoxane) is effective in both models after oral treatment but inhibits thrombus formation more strongly in the arterio-venous shunt model. Treatment with Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments, the coagulation time as measured by the Thrombotest is prolonged to the same extent.

Synonyms	Ph 137, Dicumoxane
Molecular Weight	380.35
Formula	C21H16O7
CAS No.	4366-18-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Vogel GM, et al. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans. Thromb Res. 1989 Jun 1;54(5):399-410.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Coumetarol 4366-18-1 Ph 137 Dicumoxane inhibitor inhibit

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