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DC0-NH2
Catalog No. T10968Cas No. 615538-51-7
The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then adenine residue is alkylated by its propabenzindole (CBI) component.
DC0-NH2
Catalog No. T10968Cas No. 615538-51-7
The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then adenine residue is alkylated by its propabenzindole (CBI) component.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then ade |
| In vitro | DC0-NH2 (0-3 nM; 72 hours), in the vitality test of breast cancer cell lines, has a high anti-proliferative effect on Ramos, Namalwa and HL60 / s cells, inhibits the proliferation of Namalwa and HL60 / s cells The IC50 values were 7 pM and 5 pM, respectively, and the inhibition range of COLO205 cells was within 100 pM. |
| Molecular Weight | 550.01 |
| Formula | C31H24ClN5O3 |
| Cas No. | 615538-51-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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