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DM4-SMe

Catalog No. T11059   CAS 796073-68-2

DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.

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DM4-SMe Chemical Structure
DM4-SMe, CAS 796073-68-2
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50 mg Inquiry $ 2,110.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SMe on KB cells was 0.026 nM.
Molecular Weight 826.46
Formula C39H56ClN3O10S2
CAS No. 796073-68-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. 2. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

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Keywords

DM4-SMe 796073-68-2 Others DM4SMe DM4 SMe DM-4-SMe inhibitor inhibit

 

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