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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $89 | In Stock | |
1 mL x 10 mM (in DMSO) | $68 | In Stock |
Description | DSM265 (PfSPZ) is a dihydroorotic acid dehydrogenase inhibitor with antimalarial activity (IC50: 8.9 nM).DSM265 inhibits the growth of Pf3D7 parasites and can be used for the treatment and prophylaxis of malaria infections. |
In vivo | In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activity[2]. |
Alias | PfSPZ |
Molecular Weight | 415.33 |
Formula | C14H12F7N5S |
Cas No. | 1282041-94-4 |
Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (72.23 mM) Ethanol: 5 mg/mL (12.04 mM) H2O: < 0.1 mg/mL (insoluble.) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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