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PHGDH-IN-3
Catalog No. T73143Cas No. 2893778-31-7
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
PHGDH-IN-3
Catalog No. T73143Cas No. 2893778-31-7
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $355 | In Stock | |
| 25 mg | $569 | In Stock | |
| 50 mg | $762 | In Stock | |
| 100 mg | $987 | In Stock | |
| 500 mg | $1,980 | In Stock |
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ALDH1A3-IN-3
T6434718962-05-5
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Purity:98.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research. |
| Targets&IC50 | PHGDH:2.8 μM, PHGDH:2.33 μM |
| In vitro | PHGDH-IN-3 (compound D8) exhibits strong enzymatic inhibitory activity with an IC50 value of 2.8 μM and demonstrates high binding affinity for PHGDH protein with a Kd value of 2.33 μM. It is particularly effective against cell lines with amplified or overexpressed PHGDH genes and restricts de novo serine synthesis from glucose in MDA-MB-468 cells.[1] |
| In vivo | PHGDH-IN-3 (compound D8) (1, 3 mg/kg; p.o., i.v.) exhibits excellent in vivo pharmacokinetic properties.[1] Additionally, PHGDH-IN-3 (12.5, 25, 50 mg/kg; i.p.; once daily for 31 days) demonstrated significant antitumor effects in a PC9 xenograft mouse model.[1] |
| Molecular Weight | 495.55 |
| Formula | C24H18FN3O4S2 |
| Cas No. | 2893778-31-7 |
Storage & Solubility Information
| Storage | store at low temperature | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (181.6 mM), Sonication and heating to 70℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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