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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $67 | In Stock | |
2 mg | $97 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $279 | In Stock | |
25 mg | $515 | In Stock | |
50 mg | $747 | In Stock | |
100 mg | $1,050 | In Stock | |
500 mg | $2,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $178 | In Stock |
Description | (R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. |
In vitro | (R)-GNE-140 (5 μM) inhibits proliferation in 37 of 347 cancer cell lines. (R)-GNE-140 has an inhibitory effect on two chondrosarcomas (bone) cancer cell lines that harbor IDH1 mutations (IC50: 0.8 mΜ). |
In vivo | (R)-GNE-140 (5 mg/kg) has high bioavailability in mice. (R)-GNE-140 (50-200 mg/kg, p.o.) has greater exposure. |
Alias | GNE-140 |
Molecular Weight | 499.04 |
Formula | C25H23ClN2O3S2 |
Cas No. | 2003234-63-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | DMSO: 9.38 mg/mL (18.79 mM) ![]() H2O: < 0.1 mg/mL (insoluble) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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