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ELA-14(human) acetate

Catalog No. TP1923L1 CAS TP1923L1

Synonyms: ELA-14(human) acetate (1886973-05-2 free base)

ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.

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ELA-14(human) acetate, CAS TP1923L1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
Targets&IC50	β-arrestin-2:166 nM(EC50), Gαi1:8.6 nM(EC50)
In vitro	ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
In vivo	ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1].

Synonyms	ELA-14(human) acetate (1886973-05-2 free base)
Molecular Weight	1767.09
Formula	C77H123N25O19S2
CAS No.	TP1923L1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 100 mg/ml (56.59 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72.

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Keywords

ELA-14(human) acetate TP1923L1 GPCR/G Protein Apelin receptor ELA 14(human) acetate ELA-14(human) acetate (1886973-05-2 free base) ELA14(human) acetate Inhibitor inhibitor inhibit

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