Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
Description | ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide. |
Targets&IC50 | β-arrestin-2:166 nM(EC50), Gαi1:8.6 nM(EC50) |
In vitro | ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1]. |
In vivo | ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1]. |
Synonyms | ELA-14(human) acetate (1886973-05-2 free base) |
Molecular Weight | 1767.09 |
Formula | C77H123N25O19S2 |
CAS No. | TP1923L1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 100 mg/ml (56.59 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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ELA-14(human) acetate TP1923L1 GPCR/G Protein Apelin receptor ELA 14(human) acetate ELA-14(human) acetate (1886973-05-2 free base) ELA14(human) acetate Inhibitor inhibitor inhibit