ELA-14(human) acetate

ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.

Catalog No. TP1923L1

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Purity:97.20%

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ELA-14(human) acetate

Catalog No. TP1923L1

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Pack Size	Price	Availability
1 mg	$57	In Stock
5 mg	$213	In Stock
10 mg	$320	In Stock
25 mg	$518	In Stock
50 mg	$713	In Stock
100 mg	$948	In Stock
200 mg	$1,270	In Stock

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Product Introduction

Bioactivity

Description	ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
Targets&IC50	Gαi1:8.6 nM(EC50), β-arrestin2:166 nM(EC50)
In vitro	ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
In vivo	ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1].
Alias	ELA-14(human) acetate (1886973-05-2 free base)

Chemical Properties

Molecular Weight	1767.09
Formula	C₇₇H₁₂₃N₂₅O₁₉S₂
Cas No.

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/ml (56.59 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.5659 mL	2.8295 mL	5.6590 mL	28.2951 mL
5 mM	0.1132 mL	0.5659 mL	1.1318 mL	5.6590 mL
10 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8295 mL
20 mM	0.0283 mL	0.1415 mL	0.2830 mL	1.4148 mL
50 mM	0.0113 mL	0.0566 mL	0.1132 mL	0.5659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc