Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,270.00 | |
50 mg | 10-14 weeks | $ 2,980.00 | |
100 mg | 10-14 weeks | $ 4,000.00 |
Description | Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM). |
Targets&IC50 | Topoisomerase I:50 nM, protein kinase C:160 μM |
In vitro | Edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner, in the presence of human colon cancer cells labeled with 3Hthymidine [1]. |
In vivo | Edotecarin causes tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect [1]. Combination treatment of edotecarin plus irinotecan improves the antitumor activity in vivo compared with either agent alone [2]. |
Synonyms | PF 804950, J 107088 |
Molecular Weight | 608.55 |
Formula | C29H28N4O11 |
CAS No. | 174402-32-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Edotecarin 174402-32-5 DNA Damage/DNA Repair Topoisomerase PF 804950 J 107088 J-107088 J107088 PF-804950 PF804950 inhibitor inhibit