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Edotecarin

Catalog No. T15200   CAS 174402-32-5
Synonyms: PF 804950, J 107088

Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).

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Edotecarin Chemical Structure
Edotecarin, CAS 174402-32-5
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 2,270.00
50 mg 10-14 weeks $ 2,980.00
100 mg 10-14 weeks $ 4,000.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).
Targets&IC50 Topoisomerase I:50 nM, protein kinase C:160 μM
In vitro Edotecarin (0.6 μmol/L) increases the formation of DNA-protein complexes in a time-dependent manner, in the presence of human colon cancer cells labeled with 3Hthymidine [1].
In vivo Edotecarin causes tumor growth delays ranging from 10.45 days at the lowest dose (3 mg/kg) to 24.83 days at the highest (100 mg/kg). Edotecarin produces an 83% increase in survival in mice bearing intracranial D-456MG glioma and shows a strong antimetastatic effect [1]. Combination treatment of edotecarin plus irinotecan improves the antitumor activity in vivo compared with either agent alone [2].
Synonyms PF 804950, J 107088
Molecular Weight 608.55
Formula C29H28N4O11
CAS No. 174402-32-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Saif MW, et al. Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36. 2. Ciomei M, et al. Antitumor efficacy of edotecarin as a single agent and in combination with chemotherapy agents in a xenograft model. Clin Cancer Res. 2006 May 1;12(9):2856-61.

Related Products

Related compounds with same targets
Topoisomerase IV inhibitor 1 CPT-Se3 Topoisomerase IV inhibitor 2 Irinotecan Sophoridine Rubicordifolin CPT-Se4 Niranthin

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Keywords

Edotecarin 174402-32-5 DNA Damage/DNA Repair Topoisomerase PF 804950 J 107088 J-107088 J107088 PF-804950 PF804950 inhibitor inhibit

 

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