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Exemestane

Catalog No. T1587   CAS 107868-30-4
Synonyms: EXE, FCE 24304, PNU155971

Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

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Exemestane Chemical Structure
Exemestane, CAS 107868-30-4
Pack Size Availability Price/USD Quantity
10 mg In stock $ 50.00
25 mg In stock $ 80.00
50 mg In stock $ 98.00
100 mg In stock $ 126.00
200 mg In stock $ 189.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.73%
Purity: 99.35%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.
Targets&IC50 Aromatase (rat):40 nM, Aromatase (human):30 nM
Kinase Assay Assays with human placental aromatase: Microsomes are prepared from human placenta and stored at -80℃. The rate of aromatization is determined by measuring the tritiated water released from [1β-3H]A. The assay is carried out in a final volume of 1 mL, in 10 mM phosphate buffer, pH 7.5, containing 100 mM KCl, 1 mM EDTA, 1 mM dithiothreitol, 100 μM NADPH, the enzyme preparation and the appropriate concentrations of Exemestane (in duplicate) and the substrate. After a 10 min incubation at 37 ℃, the assay is terminated by the addition of 4 mL cold chloroform. The acqueous phase is treated with a charcoal suspension, the supernatant is removed and counted for radioactivity by liquid scintillation in Rialuma. For the determination of the IC50 values, various concentrations of Exemestane are incubated with 20 μg of microsomal protein, in the presence of a fixed amount (50 nM) of [3H]A.
Cell Research hFOB is treated with steroids and Exemestane for 24 hours, when specimens are harvested and evaluated for cell proliferation using the WST-8 method. Optical densities (OD, 450 nm) are evaluated using a SpectraMax 190 microplate reader and Softmax Pro 4.3 microplate analysis software. The status of proliferation (%) is calculated according to the following equation: (cell OD value after test materials treated /vehicle control cell OD value)× 10(Only for Reference)
Synonyms EXE, FCE 24304, PNU155971
Molecular Weight 296.4
Formula C20H24O2
CAS No. 107868-30-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29.6 mg/mL (100 mM)

Ethanol: 22.2 mg/mL (75 mM)

TargetMolReferences and Literature

1. Di Salle E, et al. J Steroid Biochem Mol Biol, 1994, 49(4-6), 289-294. 2. Miki Y, et al. Bone, 2007, 40(4), 876-887. 3. Wang X, et al. Cancer Res, 2006, 66(21), 10281-10286. 4. Goss PE, et al. Clin Cancer Res, 2004, 10(17), 5717-5723. 5. Zaccheo T, et al. J Steroid Biochem Mol Biol, 1993, 44(4-6), 677-680.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Pediatric Drug Library Inhibitor Library Anti-Breast Cancer Compound Library Orally Active Compound Library Drug-Fragment Library FDA-Approved & Pharmacopeia Drug Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Exemestane 107868-30-4 Endocrinology/Hormones Aromatase PNU 155971 alkaline Inhibitor 5α-dihydrotestosterone EXE PNU-155971 FCE24304 inhibit phosphatase Steroidal FCE 24304 androstenedione FCE-24304 PNU155971 inhibitor

 

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