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Gadolinium chloride

Catalog No. T22795 CAS 10138-52-0

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

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Gadolinium chloride, CAS 10138-52-0

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Purity: 98%

Biological Description

Chemical Properties

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Description

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist

In vitro

Gadolinium chloride (GdCl ) , a well-known Kupffer/foam cell inhibitor, at late stages of NPC liver disease and compared it with NPC1 genetic rescue in hepatocytes in vivo.?GdCl treatment successfully blocked the endocytic capacity of hepatic Kupffer/foam measured by India ink endocytosis, decreased the levels CD68-A marker of Kupffer cells in the liver-and normalized the transaminase levels in serum of NPC mice to a similar extent to those obtained by genetic Npc1 rescue of liver cells.?Gadolinium salts are widely used as magnetic resonance imaging (MRI) contrasts.?This study opens the possibility of targeting foam cells with gadolinium or by other means for improving NPC liver disease.?Synopsis: Gadolinium chloride can effectively rescue some parameters of liver dysfunction in NPC mice and its potential use in patients should be carefully evaluated.

Molecular Weight	263.61
Formula	GdCl3
CAS No.	10138-52-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 9.85mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Klein A D , JE Oyarzún, Cortez C , et al. Gadolinium Chloride Rescues Niemann–Pick Type C Liver Damage[J]. International Journal of Molecular Sciences, 2018, 19(11):3599.

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Keywords

Gadolinium chloride 10138-52-0 GPCR/G Protein CaSR specific GdCl3 GdCl 3 GdCl-3 inhibit calcium-sensing receptor Inhibitor H9c2 cardiovascular Calcium-sensing receptor Gadolinium inhibitor

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