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Garenoxacin

Catalog No. T7179 CAS 194804-75-6

Synonyms: 加雷沙星, BMS284756

Garenoxacin is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.

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Garenoxacin, CAS 194804-75-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Garenoxacin is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
In vivo	The mean maximum plasma concentration (Cmax ) was 3.00 ± 1.12 μg/mL, time to maximum plasma concentration (Tmax ) was 3.0 ± 2.0 hours, and area under the curve for 24 hours (AUC0-24 ) was 40.7 ± 16.7 μg·h/mL. The half-life (T1/2 ) of GRNX could not be calculated because plasma concentrations remained high 24 hours after administration. Cmax was strongly associated with the GRNX dose per kilogram body weight (r = 0.85, P = 0.03).Clinically, fever resolved within 3 days of GRNX administration and C-reactive protein levels returned to normal 14 days after administration. One patient experienced temporary increases in serum transaminase levels[1].
Animal Research	Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography[1].

Synonyms	加雷沙星, BMS284756
Molecular Weight	426.42
Formula	C23H20F2N2O4
CAS No.	194804-75-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 2 mg/mL (4.69 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Aoyama T , Kamata K , Kishino S . Garenoxacin pharmacokinetics in patients undergoing maintenance hemodialysis[J]. Hemodialysis International, 2016. 2. Yuka Y , Tatsuya S , Satoshi N , et al. Proposed Pharmacokinetic-Pharmacodynamic Breakpoint of Garenoxacin and Other Quinolones[J]. Japanese Journal of Infectious Diseases, 2017, 70(6):616-620.

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Keywords

Garenoxacin 194804-75-6 微生物学 Antibacterial S. pneumonia Swiss mice Inhibitor Antibiotic DNA/RNA Synthesis Topoisomerase S. aureus gyrase mycoplasmas topoisomerase IV BMS284756 BMS-284756 ureaplasmas inhibit BMS 284756 Bacterial inhibitor

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