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Garenoxacin

Catalog No. T7179 CAS 194804-75-6

Synonyms: BMS284756

Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.

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Garenoxacin, CAS 194804-75-6

Pack Size	Availability	Price/USD
5 mg	4-5 weeks	$ 275.00
10 mg	4-5 weeks	$ 413.00
25 mg	4-5 weeks	$ 880.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
In vivo	The mean maximum plasma concentration (Cmax ) was 3.00 ± 1.12 μg/mL, time to maximum plasma concentration (Tmax ) was 3.0 ± 2.0 hours, and area under the curve for 24 hours (AUC0-24 ) was 40.7 ± 16.7 μg·h/mL. The half-life (T1/2 ) of GRNX could not be calculated because plasma concentrations remained high 24 hours after administration. Cmax was strongly associated with the GRNX dose per kilogram body weight (r = 0.85, P = 0.03).Clinically, fever resolved within 3 days of GRNX administration and C-reactive protein levels returned to normal 14 days after administration. One patient experienced temporary increases in serum transaminase levels[1].
Animal Research	Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography[1].

Synonyms	BMS284756
Molecular Weight	426.41
Formula	C23H20F2N2O4
CAS No.	194804-75-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2 mg/mL (4.69 mM)

References and Literature

1. Aoyama T , Kamata K , Kishino S . Garenoxacin pharmacokinetics in patients undergoing maintenance hemodialysis[J]. Hemodialysis International, 2016. 2. Yuka Y , Tatsuya S , Satoshi N , et al. Proposed Pharmacokinetic-Pharmacodynamic Breakpoint of Garenoxacin and Other Quinolones[J]. Japanese Journal of Infectious Diseases, 2017, 70(6):616-620.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Garenoxacin 194804-75-6 Microbiology/Virology Antibacterial S. pneumonia Swiss mice Inhibitor Antibiotic BMS 284756 BMS-284756 BMS284756 DNA/RNA Synthesis Topoisomerase S. aureus gyrase mycoplasmas topoisomerase IV ureaplasmas inhibit Bacterial inhibitor

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