Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Garenoxacin is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
Description | Garenoxacin is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections. |
In vivo | The mean maximum plasma concentration (Cmax ) was 3.00 ± 1.12 μg/mL, time to maximum plasma concentration (Tmax ) was 3.0 ± 2.0 hours, and area under the curve for 24 hours (AUC0-24 ) was 40.7 ± 16.7 μg·h/mL. The half-life (T1/2 ) of GRNX could not be calculated because plasma concentrations remained high 24 hours after administration. Cmax was strongly associated with the GRNX dose per kilogram body weight (r = 0.85, P = 0.03).Clinically, fever resolved within 3 days of GRNX administration and C-reactive protein levels returned to normal 14 days after administration. One patient experienced temporary increases in serum transaminase levels[1]. |
Animal Research | Six male patients with infections who were undergoing MH received 200 mg GRNX once daily. Blood samples were taken before and at 1, 2, 4, 6, 12, and 24 hours after GRNX administration. Plasma GRNX concentrations were measured using high-performance liquid chromatography[1]. |
Synonyms | 加雷沙星, BMS284756 |
Molecular Weight | 426.42 |
Formula | C23H20F2N2O4 |
CAS No. | 194804-75-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 2 mg/mL (4.69 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Garenoxacin 194804-75-6 微生物学 Antibacterial S. pneumonia Swiss mice Inhibitor Antibiotic DNA/RNA Synthesis Topoisomerase S. aureus gyrase mycoplasmas topoisomerase IV BMS284756 BMS-284756 ureaplasmas inhibit BMS 284756 Bacterial inhibitor