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Cat No. | Product Name | Synonyms | Targets |
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T78866 | DNA Gyrase-IN-9 | DNA/RNA Synthesis | |
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase. It exhibits a minimum inhibitory concentration (MIC) of 0.5-2 µg/mL for Gram-positive bacteria inhibition and a minimum bactericidal ... | |||
T62895 | DNA Gyrase-IN-4 | ||
DNA Gyrase-IN-4 (compound 8p) is a potent inhibitor of DNA cyclooxygenase (IC50: 0.13 μM). (MIC: 0.05 μg/ml), Salmonella (MIC: 0.05 μg/ml) and Escherichia coli (MIC: 8 μg/ml). | |||
T63442 | DNA Gyrase-IN-2 | ||
DNA Gyrase-IN-2 is a bacterial DNA cyclooxygenase B inhibitor that acts on Escherichia coli DNA cyclooxygenase (IC50: 3.29-10.49 μM) and Mycobacterium tuberculosis DNA cyclooxygenase (IC50: 4.41-5.61 μM), exhibiting anti... | |||
T61937 | DNA Gyrase-IN-3 | ||
DNA Gyrase-IN-3 (Compound 28) is an inhibitor of bacterial DNA gyrase B. The IC50 of DNA Gyrase-IN-3 inhibits Escherichia coli DNA rotatase is 5.41-15.64 μM. DNA Gyrase-IN-3 shows anti-tuberculosis and antibacterial acti... | |||
T63395 | DNA Gyrase-IN-5 | ||
DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains. | |||
T78712 | DNA Gyrase-IN-8 | DNA/RNA Synthesis | |
DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1]. | |||
T63681 | DNA Gyrase-IN-1 | ||
DNA Gyrase-IN-1 is a potent and selective DNA promoter inhibitor (IC50: 2.6 μM). DNA Gyrase-IN-1 inhibits Mycobacterium tuberculosis (Mtb) activity well (MIC: 0.49 μM). DNA Gyrase-IN-1 can be used to study tuberculosis. | |||
T74848 | DNA Gyrase-IN-6 | ||
Antibacterial agent 138, a benzothiazole inhibitor, targets bacterial DNA gyrase and topoisomerase IV, exhibiting both favorable solubility and plasma protein binding. It demonstrates antibacterial activity against Gram-... | |||
T79240 | DNA gyrase B-IN-2 | ||
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition ... | |||
T62792 | 14α-Demethylase/DNA Gyrase-IN-1 | ||
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity. | |||
T64012 | DNA gyrase B-IN-1 | ||
DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM). | |||
T78776 | DNA gyrase B-IN-3 | DNA/RNA Synthesis | |
DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1]. | |||
T62389 | 14α-Demethylase/DNA Gyrase-IN-2 | ||
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity. | |||
T8747 | Levofloxacin hydrochloride | DNA gyrase , Topoisomerase | |
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh... | |||
T13231L | Trovafloxacin mesylate | Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial | |
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ... | |||
T7865 | Danofloxacin | Danofloxacino,Danofloxacin free base,Danofloxacine | Others , DNA/RNA Synthesis , Antibacterial , Antibiotic |
Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine. | |||
T0909L | Nalidixic acid sodium salt | Baktogram,Sodium nalidixate | Topoisomerase , Antibacterial , Antibiotic |
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum. | |||
T7804 | Garenoxacin mesylate hydrate | Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) | Antibacterial |
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains. | |||
T0717L | Enoxacin | NSC 629661,AT 2266,Pd107779,CI 919 | DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic |
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | |||
T1451 | Levofloxacin hydrate | Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate | DNA gyrase , Topoisomerase , Antibacterial , Antibiotic |
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c... | |||
T13231 | Trovafloxacin | DNA gyrase , Topoisomerase , Antibacterial , Antibiotic | |
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive. | |||
T0717 | Enoxacin hydrate | CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate | DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic |
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. | |||
T7179 | Garenoxacin | BMS284756 | Antibacterial |
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections. | |||
T2353 | BRD7116 | BRD7716 | DNA gyrase , Antibacterial |
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity. | |||
T20510 | Novobiocin | U-6391,U 6391,U6391,Cathomycin,Albamycin | Apoptosis , Virus Protease , HSP , DNA gyrase , Antibacterial , Antibiotic |
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity an... | |||
T1095 | Sparfloxacin | AT-4140,PD 131501,Zagam,CI-978 | DNA gyrase , Topoisomerase , Antibacterial , Antibiotic |
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription. | |||
T0425L | Pefloxacin Mesylate Dihydrate | Pefloxacinium mesylate dihydrate,1589 RB | Topoisomerase , Antibacterial , Antibiotic |
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase). | |||
T1294 | Fleroxacin | AM-833,RO 23-6240 | DNA gyrase , Topoisomerase , Antibacterial , Antibiotic |
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase. | |||
T8835 | Tosufloxacin hydrochloride | A-61827 hydrochloride,T-3262 hydrochloride | Antibacterial |
Tosufloxacin hydrochloride is a fluoroquinolone antibacterial agent used to treat bacterial infections.Tosufloxacin hydrochloride is also a bacterial Topo (DNA gyrase, topoisomerase)) inhibitor. | |||
T1640 | Ciprofloxacin | Ciproxan,Ciprobay,Bay o 9867,Bay-09867 | Topoisomerase , Antibacterial , Antibiotic |
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria. | |||
T0902 | Ofloxacin | DL8280,Hoe-280,Floxin,Tarivid,Oxaldin | Topoisomerase , Antibacterial , Antibiotic |
Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting i... | |||
T1293 | Gatifloxacin | BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155 | Topoisomerase , Antibacterial , Antibiotic |
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. | |||
T0116 | Balofloxacin | DNA gyrase , Antibacterial , Antibiotic | |
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase. | |||
TQ0063 | Zoliflodacin | ETX0914,AZD0914 | DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial |
Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aur... | |||
T67826 | Alalevonadifloxacin | DNA gyrase , Topoisomerase , Antibacterial | |
Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin is potentially useful in the treatment of bacterial Gram-p... | |||
T1060 | Flumequine | Flumigal,R-802 | Topoisomerase , Antibacterial , Antibiotic |
Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necess... | |||
T1625 | Lomefloxacin hydrochloride | Lomefloxacin HCl,Okacyn,Maxaquin | Topoisomerase , Antibacterial , Antibiotic |
Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during... | |||
T1492 | Gemifloxacin mesylate | LB-20304a,SB-265805S,Gemifloxacin mesylate | DNA gyrase , Topoisomerase , Antibacterial |
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of... | |||
T26588 | Albicidin | ||
Albicidin is a DNA gyrase inhibitor produced by Xanthomonas albilineans. | |||
T25265 | Clorobiocin | RP18631,RP 18631,RP-18631 | |
Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase. | |||
T23924 | Cyclothialidine | Ro 09-1437 | |
Cyclothialidine is an inhibitor of DNA gyrase. | |||
T1293L | Gatifloxacin sesquihydrate | Gatifloxacin | |
Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia. | |||
T24126 | Gyramide A | Gyramide-A | |
Gyramide A is an inhibitor of bacterial DNA gyrase. It shows antimicrobial activity and inhibits bacterial cell division. | |||
T26717 | AZD-5099 | AZD5099 | |
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection. | |||
T13326 | SPR719 | VXc-486 | Others |
SPR719 is an inhibitor of gyrase B, has bactericidal activity. | |||
T23578 | (S)-Gyramide A | (S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6 | |
(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division. | |||
T68872 | Cinodine hydrochloride | ||
Cinodine hydrochloride is a glycocinnamoylspermidine antibiotic; gyrase inhibitor found in Nocardia. | |||
T69147 | Cinodine (free base) | ||
Cinodine (free base) is a glycocinnamoylspermidine antibiotic; gyrase inhibitor found in Nocardia. | |||
T1451L | Levofloxacin sodium | ||
Levofloxacin sodium is a synthetic fluoroquinolones antibacterial. It inhibits the supercoiling activity of bacterial DNA gyrase, so that halting DNA replication. | |||
T22797 | Gatifloxacin mesylate | Others | |
Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. |
Cat No. | Product Name | Synonyms | Targets |
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T0909 | Nalidixic acid | NSC-82174 | Topoisomerase , Antibacterial , Antibiotic |
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE. | |||
T6567 | Levofloxacin | Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin | Topoisomerase , Antibacterial , Antibiotic |
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections. | |||
T1276 | Danofloxacin mesylate | CP 76136-27 | DNA/RNA Synthesis , Antibacterial , Antibiotic |
Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase. | |||
T7786 | Tryptanthrin | DNA gyrase | |
Tryptanthrin is a natural DNA gyrase inhibitor. | |||
TQ0184 | Chebulinic acid | ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad | |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. | |||
T0974 | Novobiocin Sodium | Albamycinsodium,Cathomycin,Albamycin | Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy |
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim... | |||
T10838 | Closthioamide | Antibacterial | |
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM). | |||
T36303 | Psammaplin A | ||
Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobi... |
Cat No. | Product Name | Species | Expression System |
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TMPH-00558 | 30S ribosomal protein S11 Protein, E. coli, Recombinant (His) | E. coli | E. coli |
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa... |