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Search Results for " gyrase "

Targets

72

Compounds

8

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T78866 DNA Gyrase-IN-9 DNA/RNA Synthesis
DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase. It exhibits a minimum inhibitory concentration (MIC) of 0.5-2 µg/mL for Gram-positive bacteria inhibition and a minimum bactericidal ...
T62895 DNA Gyrase-IN-4
DNA Gyrase-IN-4 (compound 8p) is a potent inhibitor of DNA cyclooxygenase (IC50: 0.13 μM). (MIC: 0.05 μg/ml), Salmonella (MIC: 0.05 μg/ml) and Escherichia coli (MIC: 8 μg/ml).
T63442 DNA Gyrase-IN-2
DNA Gyrase-IN-2 is a bacterial DNA cyclooxygenase B inhibitor that acts on Escherichia coli DNA cyclooxygenase (IC50: 3.29-10.49 μM) and Mycobacterium tuberculosis DNA cyclooxygenase (IC50: 4.41-5.61 μM), exhibiting anti...
T61937 DNA Gyrase-IN-3
DNA Gyrase-IN-3 (Compound 28) is an inhibitor of bacterial DNA gyrase B. The IC50 of DNA Gyrase-IN-3 inhibits Escherichia coli DNA rotatase is 5.41-15.64 μM. DNA Gyrase-IN-3 shows anti-tuberculosis and antibacterial acti...
T63395 DNA Gyrase-IN-5
DNA Gyrase-IN-5 is a potent inhibitor of DNA gyrase (IC50: 0.10 μM) and has an antibacterial effect on both wild-type and drug-resistant strains.
T78712 DNA Gyrase-IN-8 DNA/RNA Synthesis
DNA Gyrase-IN-8 is a potent inhibitor of DNA gyrase, demonstrating antimicrobial activity with an IC50 of 8.45 µM [1].
T63681 DNA Gyrase-IN-1
DNA Gyrase-IN-1 is a potent and selective DNA promoter inhibitor (IC50: 2.6 μM). DNA Gyrase-IN-1 inhibits Mycobacterium tuberculosis (Mtb) activity well (MIC: 0.49 μM). DNA Gyrase-IN-1 can be used to study tuberculosis.
T74848 DNA Gyrase-IN-6
Antibacterial agent 138, a benzothiazole inhibitor, targets bacterial DNA gyrase and topoisomerase IV, exhibiting both favorable solubility and plasma protein binding. It demonstrates antibacterial activity against Gram-...
T79240 DNA gyrase B-IN-2
DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE pathogens. The compound exhibits potent nanomolar-range inhibition ...
T62792 14α-Demethylase/DNA Gyrase-IN-1
14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
T64012 DNA gyrase B-IN-1
DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM).
T78776 DNA gyrase B-IN-3 DNA/RNA Synthesis
DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].
T62389 14α-Demethylase/DNA Gyrase-IN-2
14α-Demethylase/DNA Gyrase-IN-2 (Compound 6a) is a potent inhibitor of 14α-Demethylase/DNA Gyrase with antibacterial activity.
T8747 Levofloxacin hydrochloride DNA gyrase , Topoisomerase
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inh...
T13231L Trovafloxacin mesylate Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...
T7865 Danofloxacin Danofloxacino,Danofloxacin free base,Danofloxacine Others , DNA/RNA Synthesis , Antibacterial , Antibiotic
Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.
T0909L Nalidixic acid sodium salt Baktogram,Sodium nalidixate Topoisomerase , Antibacterial , Antibiotic
Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.
T7804 Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate) Antibacterial
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.
T0717L Enoxacin NSC 629661,AT 2266,Pd107779,CI 919 DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
T1451 Levofloxacin hydrate Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial c...
T13231 Trovafloxacin DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
T0717 Enoxacin hydrate CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
T7179 Garenoxacin BMS284756 Antibacterial
Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.
T2353 BRD7116 BRD7716 DNA gyrase , Antibacterial
BRD7116 competitively binds to bacterial DNA gyrase, with cell-non-autonomous anti-leukemia activity.
T20510 Novobiocin U-6391,U 6391,U6391,Cathomycin,Albamycin Apoptosis , Virus Protease , HSP , DNA gyrase , Antibacterial , Antibiotic
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity an...
T1095 Sparfloxacin AT-4140,PD 131501,Zagam,CI-978 DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.
T0425L Pefloxacin Mesylate Dihydrate Pefloxacinium mesylate dihydrate,1589 RB Topoisomerase , Antibacterial , Antibiotic
Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).
T1294 Fleroxacin AM-833,RO 23-6240 DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.
T8835 Tosufloxacin hydrochloride A-61827 hydrochloride,T-3262 hydrochloride Antibacterial
Tosufloxacin hydrochloride is a fluoroquinolone antibacterial agent used to treat bacterial infections.Tosufloxacin hydrochloride is also a bacterial Topo (DNA gyrase, topoisomerase)) inhibitor.
T1640 Ciprofloxacin Ciproxan,Ciprobay,Bay o 9867,Bay-09867 Topoisomerase , Antibacterial , Antibiotic
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
T0902 Ofloxacin DL8280,Hoe-280,Floxin,Tarivid,Oxaldin Topoisomerase , Antibacterial , Antibiotic
Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting i...
T1293 Gatifloxacin BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155 Topoisomerase , Antibacterial , Antibiotic
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
T0116 Balofloxacin DNA gyrase , Antibacterial , Antibiotic
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
TQ0063 Zoliflodacin ETX0914,AZD0914 DNA gyrase , DNA/RNA Synthesis , Topoisomerase , Antibacterial
Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aur...
T67826 Alalevonadifloxacin DNA gyrase , Topoisomerase , Antibacterial
Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin is potentially useful in the treatment of bacterial Gram-p...
T1060 Flumequine Flumigal,R-802 Topoisomerase , Antibacterial , Antibiotic
Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necess...
T1625 Lomefloxacin hydrochloride Lomefloxacin HCl,Okacyn,Maxaquin Topoisomerase , Antibacterial , Antibiotic
Lomefloxacin hydrochloride (Okacyn) inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during...
T1492 Gemifloxacin mesylate LB-20304a,SB-265805S,Gemifloxacin mesylate DNA gyrase , Topoisomerase , Antibacterial
Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of...
T26588 Albicidin
Albicidin is a DNA gyrase inhibitor produced by Xanthomonas albilineans.
T25265 Clorobiocin RP18631,RP 18631,RP-18631
Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.
T23924 Cyclothialidine Ro 09-1437
Cyclothialidine is an inhibitor of DNA gyrase.
T1293L Gatifloxacin sesquihydrate Gatifloxacin
Gatifloxacin sesquihydrate, a bacterial DNA gyrase inhibitor, is used to treat tuberculosis and pneumonia.
T24126 Gyramide A Gyramide-A
Gyramide A is an inhibitor of bacterial DNA gyrase. It shows antimicrobial activity and inhibits bacterial cell division.
T26717 AZD-5099 AZD5099
AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.
T13326 SPR719 VXc-486 Others
SPR719 is an inhibitor of gyrase B, has bactericidal activity.
T23578 (S)-Gyramide A (S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6
(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division.
T68872 Cinodine hydrochloride
Cinodine hydrochloride is a glycocinnamoylspermidine antibiotic; gyrase inhibitor found in Nocardia.
T69147 Cinodine (free base)
Cinodine (free base) is a glycocinnamoylspermidine antibiotic; gyrase inhibitor found in Nocardia.
T1451L Levofloxacin sodium
Levofloxacin sodium is a synthetic fluoroquinolones antibacterial. It inhibits the supercoiling activity of bacterial DNA gyrase, so that halting DNA replication.
T22797 Gatifloxacin mesylate Others
Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Compounds

DNA Gyrase-IN-9
T78866
Synonym:
Target: DNA/RNA Synthesis
DNA Gyrase-IN-4
T62895
Synonym:
Target:
DNA Gyrase-IN-2
T63442
Synonym:
Target:
DNA Gyrase-IN-3
T61937
Synonym:
Target:
DNA Gyrase-IN-5
T63395
Synonym:
Target:
DNA Gyrase-IN-8
T78712
Synonym:
Target: DNA/RNA Synthesis
DNA Gyrase-IN-1
T63681
Synonym:
Target:
DNA Gyrase-IN-6
T74848
Synonym:
Target:
DNA gyrase B-IN-2
T79240
Synonym:
Target:
14α-Demethylase/DNA Gyrase-IN-1
T62792
Synonym:
Target:
DNA gyrase B-IN-1
T64012
Synonym:
Target:
DNA gyrase B-IN-3
T78776
Synonym:
Target: DNA/RNA Synthesis
14α-Demethylase/DNA Gyrase-IN-2
T62389
Synonym:
Target:
Levofloxacin hydrochloride
T8747
Synonym:
Target: DNA gyrase, Topoisomerase
Trovafloxacin mesylate
T13231L
Synonym:
Target: Others, DNA/RNA Synthesis, Topoisomerase, Antibacterial
Danofloxacin
T7865
Synonym: Danofloxacino,Danofloxacin free base,Danofloxacine
Target: Others, DNA/RNA Synthesis, Antibacterial, Antibiotic
Nalidixic acid sodium salt
T0909L
Synonym: Baktogram,Sodium nalidixate
Target: Topoisomerase, Antibacterial, Antibiotic
Garenoxacin mesylate hydrate
T7804
Synonym: Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate)
Target: Antibacterial
Enoxacin
T0717L
Synonym: NSC 629661,AT 2266,Pd107779,CI 919
Target: DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic
Levofloxacin hydrate
T1451
Synonym: Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Trovafloxacin
T13231
Synonym:
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Enoxacin hydrate
T0717
Synonym: CI-919 hydrate,Enoxacin Sesquihydrate,AT-2266 hydrate
Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic
Garenoxacin
T7179
Synonym: BMS284756
Target: Antibacterial
BRD7116
T2353
Synonym: BRD7716
Target: DNA gyrase, Antibacterial
Novobiocin
T20510
Synonym: U-6391,U 6391,U6391,Cathomycin,Albamycin
Target: Apoptosis, Virus Protease, HSP, DNA gyrase, Antibacterial, Antibiotic
Sparfloxacin
T1095
Synonym: AT-4140,PD 131501,Zagam,CI-978
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Pefloxacin Mesylate Dihydrate
T0425L
Synonym: Pefloxacinium mesylate dihydrate,1589 RB
Target: Topoisomerase, Antibacterial, Antibiotic
Fleroxacin
T1294
Synonym: AM-833,RO 23-6240
Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic
Tosufloxacin hydrochloride
T8835
Synonym: A-61827 hydrochloride,T-3262 hydrochloride
Target: Antibacterial
Ciprofloxacin
T1640
Synonym: Ciproxan,Ciprobay,Bay o 9867,Bay-09867
Target: Topoisomerase, Antibacterial, Antibiotic
Ofloxacin
T0902
Synonym: DL8280,Hoe-280,Floxin,Tarivid,Oxaldin
Target: Topoisomerase, Antibacterial, Antibiotic
Gatifloxacin
T1293
Synonym: BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155
Target: Topoisomerase, Antibacterial, Antibiotic
Balofloxacin
T0116
Synonym:
Target: DNA gyrase, Antibacterial, Antibiotic
Zoliflodacin
TQ0063
Synonym: ETX0914,AZD0914
Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial
Alalevonadifloxacin
T67826
Synonym:
Target: DNA gyrase, Topoisomerase, Antibacterial
Flumequine
T1060
Synonym: Flumigal,R-802
Target: Topoisomerase, Antibacterial, Antibiotic
Lomefloxacin hydrochloride
T1625
Synonym: Lomefloxacin HCl,Okacyn,Maxaquin
Target: Topoisomerase, Antibacterial, Antibiotic
Gemifloxacin mesylate
T1492
Synonym: LB-20304a,SB-265805S,Gemifloxacin mesylate
Target: DNA gyrase, Topoisomerase, Antibacterial
Albicidin
T26588
Synonym:
Target:
Clorobiocin
T25265
Synonym: RP18631,RP 18631,RP-18631
Target:
Cyclothialidine
T23924
Synonym: Ro 09-1437
Target:
Gatifloxacin sesquihydrate
T1293L
Synonym: Gatifloxacin
Target:
Gyramide A
T24126
Synonym: Gyramide-A
Target:
AZD-5099
T26717
Synonym: AZD5099
Target:
SPR719
T13326
Synonym: VXc-486
Target: Others
(S)-Gyramide A
T23578
Synonym: (S)-Gyramide-A,(S)-534F6,(S)534F6,(S) 534F6
Target:
Cinodine hydrochloride
T68872
Synonym:
Target:
Cinodine (free base)
T69147
Synonym:
Target:
Levofloxacin sodium
T1451L
Synonym:
Target:
Gatifloxacin mesylate
T22797
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
T0909 Nalidixic acid NSC-82174 Topoisomerase , Antibacterial , Antibiotic
Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.
T6567 Levofloxacin Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin Topoisomerase , Antibacterial , Antibiotic
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
T1276 Danofloxacin mesylate CP 76136-27 DNA/RNA Synthesis , Antibacterial , Antibiotic
Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.
T7786 Tryptanthrin DNA gyrase
Tryptanthrin is a natural DNA gyrase inhibitor.
TQ0184 Chebulinic acid ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
T0974 Novobiocin Sodium Albamycinsodium,Cathomycin,Albamycin Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim...
T10838 Closthioamide Antibacterial
Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).
T36303 Psammaplin A
Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobi...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00558 30S ribosomal protein S11 Protein, E. coli, Recombinant (His) E. coli E. coli
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (Pa...
TargetMol