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Zoliflodacin

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Purity:99.82%

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COA HPLC HNMR

Zoliflodacin

Catalog No. TQ0063Cas No. 1620458-09-4

Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).

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Pack Size	Price	Availability
1 mg	$113	In Stock
5 mg	$273	In Stock
10 mg	$432	In Stock
25 mg	$716	In Stock
50 mg	$987	In Stock
100 mg	$1,370	In Stock
500 mg	$2,730	In Stock
1 mL x 10 mM (in DMSO)	$293	In Stock

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Product Introduction

Bioactivity

Description	Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
In vitro	Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA.
Alias	ETX0914, AZD0914

Chemical Properties

Molecular Weight	487.44
Formula	C22H22FN5O7
Cas No.	1620458-09-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135 mg/mL (276.95 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0515 mL	10.2577 mL	20.5153 mL	102.5767 mL
5 mM	0.4103 mL	2.0515 mL	4.1031 mL	20.5153 mL
10 mM	0.2052 mL	1.0258 mL	2.0515 mL	10.2577 mL
20 mM	0.1026 mL	0.5129 mL	1.0258 mL	5.1288 mL
50 mM	0.0410 mL	0.2052 mL	0.4103 mL	2.0515 mL
100 mM	0.0205 mL	0.1026 mL	0.2052 mL	1.0258 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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