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Guaifenesin

Catalog No. T0739 CAS 93-14-1

Synonyms: Glycerol guaiacolate, Guaiacol glyceryl ether, Guaiphenesin

Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.

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Guaifenesin, CAS 93-14-1

Pack Size	Availability	Price/USD
500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 100%

Purity: 99.69%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Guaifenesin (Guaiphenesin) is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.

In vivo

Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) produces effective and safe surgical anesthesia for over 30 minutes in New Zealand white rabbits. Guaifenesin (200 mg/kg, intravenously) combined with ketamine (50 mg/kg, intramuscularly) mildly depresses respiratory rate but heart rate and arterial blood pressure are not significantly affected. Guaifenesin (200 mg/kg, intravenously) is combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. [1] Guaifenesin (50 mg/mL) combined Xylazine (0.1 mg/mL) and Ketamine (1.0 mg/mL) results in excellent anesthetic induction and maintenance with cardiopulmonary alterations similar to those associated with isoflurane in mechanically ventilated calves. [2] Guaifenesin (150 mg/kg) decreases spectral edge frequency (SEF) and total power in pigs. [3] Guaifenesin prevents adverse anesthetic induction events caused by Propofol in horse. Guaifenesin (90 mg/kg) followed by Propofol (3 mg/kg) should be sufficient to immobilize > 99% of calm healthy adult horses. [4] Guaifenesin (100 mg/kg) produces moderate behavioral changes in the social conflict test in mice. Guaifenesin (200 mg/kg) combined with Paracetamol (200 mg/kg) causes significantly more pronounced analgesic effects that the corresponding doses of paracetamol alone in mice. [5]

Synonyms	Glycerol guaiacolate, Guaiacol glyceryl ether, Guaiphenesin
Molecular Weight	198.22
Formula	C10H14O4
CAS No.	93-14-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38 mg/mL (191.7 mM)

H2O: 23 mg/mL (116 mM)

Ethanol: 38 mg/mL (191.7 mM)

References and Literature

1. Olson ME, et al. Can J Vet Res, 1987, 51(3), 383-386. 2. Kerr CL, et al. Am J Vet Res, 2007, 68(12), 1287-1293. 3. Haga HA, et al. Am J Vet Res, 2000, 61(12), 1599-1601. 4. Brosnan RJ, et al. Am J Vet Res, 2011, 72(12), 1569-1575. 5. Dolezal T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2002, 366(6), 551-554.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library NO PAINS Compound Library Bioactive Compound Library RO5 Drug-like Natural Product Library Human Metabolite Library Immunology/Inflammation Compound Library Natural Product Library for HTS Natural Product Library Anti-infective Natural Product Library Drug-induced Liver Injury (DILI) Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Guaifenesin 93-14-1 Others sputum officinale Guajacum cough Glycerol guaiacolate Guaiacol glyceryl ether narcotic inhibit expectorant Guaiphenesin Inhibitor Linné inhibitor

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